Research Center on Aging and Department of Physiology and Biophysics
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Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe.
Neurology Aug, 2012 | Pubmed ID: 22855869
The ketogenic diet increases brain glucose and ketone uptake in aged rats: a dual tracer PET and volumetric MRI study.
Brain research Dec, 2012 | Pubmed ID: 23063891
Breath acetone as a measure of systemic ketosis assessed in a rat model of the ketogenic diet.
Clinical chemistry Jan, 2002 | Pubmed ID: 11751546
Arachidonate metabolism in neonates.
Pediatric research Mar, 2002 | Pubmed ID: 11861928
Brain sterols in the AY-9944 rat model of atypical absence seizures.
Epilepsia Jan, 2002 | Pubmed ID: 11879380
Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology Apr, 2002 | Pubmed ID: 11923081
Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial.
The American journal of clinical nutrition May, 2002 | Pubmed ID: 11976156
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.
The American journal of clinical nutrition Jul, 2002 | Pubmed ID: 12081817
Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women.
The American journal of clinical nutrition Aug, 2002 | Pubmed ID: 12145008
Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality.
The American journal of clinical nutrition Feb, 2003 | Pubmed ID: 12540417
Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3.
Journal of lipid research Feb, 2003 | Pubmed ID: 12576513
Whole-body utilization of n-3 PUFA in n-6 PUFA-deficient rats.
Lipids Feb, 2003 | Pubmed ID: 12733752
Why is carbon from some polyunsaturates extensively recycled into lipid synthesis?
Lipids Apr, 2003 | Pubmed ID: 12848297
Survival of the fattest: fat babies were the key to evolution of the large human brain.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Sep, 2003 | Pubmed ID: 14527626
Problems with essential fatty acids: time for a new paradigm?
Progress in lipid research Nov, 2003 | Pubmed ID: 14559071
Dietary alpha-linolenic acid increases the n-3 PUFA content of sow's milk and the tissues of the suckling piglet.
Lipids Oct, 2003 | Pubmed ID: 14669969
Metabolism of polyunsaturated fatty acids and ketogenesis: an emerging connection.
Prostaglandins, leukotrienes, and essential fatty acids Mar, 2004 | Pubmed ID: 14769482
Intramuscular injection of antigens and adjuvant preferentially decreases 18:2n-6 and 18:3n-3 in pig neck muscle.
Lipids Dec, 2003 | Pubmed ID: 14870924
Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols.
Journal of lipid research Nov, 2004 | Pubmed ID: 15314096
Claims to identify detrimental effects of the ketogenic diet (KD) on cognitive function in rats.
Pediatric research Oct, 2004 | Pubmed ID: 15319466
Dietary 18:3omega3 influences immune function and the tissue fatty acid response to antigens and adjuvant.
Immunology letters Aug, 2004 | Pubmed ID: 15325802
Effects of a diet high in plant sterols, vegetable proteins, and viscous fibers (dietary portfolio) on circulating sterol levels and red cell fragility in hypercholesterolemic subjects.
Lipids Feb, 2005 | Pubmed ID: 15884765
Origins and evolution of the Western diet: implications of iodine and seafood intakes for the human brain.
The American journal of clinical nutrition Aug, 2005 | Pubmed ID: 16087997
Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats.
Metabolism: clinical and experimental Sep, 2005 | Pubmed ID: 16125522
Breath acetone predicts plasma ketone bodies in children with epilepsy on a ketogenic diet.
Nutrition (Burbank, Los Angeles County, Calif.) Jan, 2006 | Pubmed ID: 16183255
Suckling rats actively recycle carbon from alpha-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates.
Pediatric research Jan, 2006 | Pubmed ID: 16326997
[Survival of the fattest: the key to human brain evolution].
Médecine sciences : M/S Jun-Jul, 2006 | Pubmed ID: 16828044
Omega-3 fatty acids, energy substrates, and brain function during aging.
Prostaglandins, leukotrienes, and essential fatty acids Sep, 2006 | Pubmed ID: 16829066
Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate.
Lipids Oct, 2006 | Pubmed ID: 17180881
Comparison of composition and absorption of sugarcane policosanols.
The British journal of nutrition Feb, 2007 | Pubmed ID: 17298709
alpha-Linolenic acid and fish oil n-3 fatty acids and cardiovascular disease risk.
The American journal of clinical nutrition Mar, 2007 | Pubmed ID: 17344517
Docosahexaenoic acid and human brain evolution: missing the forest for the trees--comments by Cunnane.
The British journal of nutrition May, 2007 | Pubmed ID: 17408531
Biosynthetic production of universally (13)C-labelled polyunsaturated fatty acids as reference materials for natural health product research.
Analytical and bioanalytical chemistry Sep, 2007 | Pubmed ID: 17486321
Automated synthesis of 11C-acetoacetic acid, a key alternate brain fuel to glucose.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Aug, 2007 | Pubmed ID: 17544283
Docosahexaenoic acid and shore-based diets in hominin encephalization: a rebuttal.
American journal of human biology : the official journal of the Human Biology Council Jul-Aug, 2007 | Pubmed ID: 17546620
Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme Aug, 2007 | Pubmed ID: 17622276
Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial.
Nutrition (Burbank, Los Angeles County, Calif.) Jan, 2008 | Pubmed ID: 17981439
Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease.
Prostaglandins, leukotrienes, and essential fatty acids Nov-Dec, 2007 | Pubmed ID: 18036804
Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Jan, 2008 | Pubmed ID: 18195289
An emerging risk factor for obesity: does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development?
The British journal of nutrition Sep, 2008 | Pubmed ID: 18307824
[11C] acetoacetate utilization by breast and prostate tumors: a PET and biodistribution study in mice.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Jul-Aug, 2008 | Pubmed ID: 18454299
Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial.
Journal of the American College of Nutrition Feb, 2008 | Pubmed ID: 18460483
Conjugated linoleic acids: why the discrepancy between animal and human studies?
Nutrition reviews Jul, 2008 | Pubmed ID: 18667017
Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly.
Lipids Nov, 2008 | Pubmed ID: 18795357
Heterogeneity in randomized controlled trials of long chain (fish) omega-3 fatty acids in restenosis, secondary prevention and ventricular arrhythmias.
Journal of the American College of Nutrition Jun, 2008 | Pubmed ID: 18838524
Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly.
Nutrition (Burbank, Los Angeles County, Calif.) Mar, 2009 | Pubmed ID: 19036560
Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate.
Epilepsia Nov, 2008 | Pubmed ID: 19049595
Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids.
The Journal of nutrition Apr, 2009 | Pubmed ID: 19244379
alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans.
Prostaglandins, leukotrienes, and essential fatty acids Feb-Mar, 2009 | Pubmed ID: 19269799
n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations.
Public health nutrition Jan, 2010 | Pubmed ID: 19433004
Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men.
The British journal of nutrition Oct, 2009 | Pubmed ID: 19828088
Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring.
Endocrinology Apr, 2010 | Pubmed ID: 20160134
Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects.
The Journal of pharmacology and experimental therapeutics Jul, 2010 | Pubmed ID: 20404010
Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain.
European journal of nuclear medicine and molecular imaging Aug, 2010 | Pubmed ID: 20437239
Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects.
PloS one , 2010 | Pubmed ID: 20532041
Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly.
Nutrition & metabolism , 2011 | Pubmed ID: 21272363
n-3 fatty acids and cardiovascular events.
The New England journal of medicine Mar, 2011 | Pubmed ID: 21366485
Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats.
Nutritional neuroscience Mar, 2011 | Pubmed ID: 21605500
Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease.
Journal of Alzheimer's disease : JAD , 2012 | Pubmed ID: 22466064
Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?
Prostaglandins, leukotrienes, and essential fatty acids Jan, 2013 | Pubmed ID: 22575581
n-3 PUFA status affects expression of genes involved in neuroenergetics differently in the fronto-parietal cortex compared to the CA1 area of the hippocampus: effect of rest and neuronal activation in the rat.
Prostaglandins, leukotrienes, and essential fatty acids Jun, 2012 | Pubmed ID: 22579067
Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition.
The American journal of clinical nutrition Jan, 2013 | Pubmed ID: 23221573
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
Nutrition (Burbank, Los Angeles County, Calif.) Apr, 2013 | Pubmed ID: 23274095
Thyroid function and cognition in the euthyroid elderly: A case-control study embedded in Quebec longitudinal study - NuAge.
Psychoneuroendocrinology Mar, 2013 | Pubmed ID: 23507188
Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study.
Nutrition research (New York, N.Y.) May, 2013 | Pubmed ID: 23684438
Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype.
Journal of lipid research Sep, 2013 | Pubmed ID: 23801662
Long-term calorie restriction has minimal impact on brain metabolite and fatty acid profiles in aged rats on a Western-style diet.
Neurochemistry international Nov, 2013 | Pubmed ID: 23974047
Brain Docosahexaenoic Acid [DHA] Incorporation and Blood Flow Are Increased in Chronic Alcoholics: A Positron Emission Tomography Study Corrected for Cerebral Atrophy.
PloS one , 2013 | Pubmed ID: 24098376
Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline.
The Proceedings of the Nutrition Society Oct, 2013 | Pubmed ID: 24103099
Maggie Roy1,
Scott Nugent1,
Sébastien Tremblay2,
Maxime Descoteaux3,
Jean-François Beaudoin2,
Luc Tremblay2,
Roger Lecomte2,4,
Stephen C Cunnane1
1Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke,
2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center, Université de Sherbrooke,
3Department of Computer Science, Université de Sherbrooke,
4Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke
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