Stephen C Cunnane

Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe.

The ketogenic diet increases brain glucose and ketone uptake in aged rats: a dual tracer PET and volumetric MRI study.

Breath acetone as a measure of systemic ketosis assessed in a rat model of the ketogenic diet.

Arachidonate metabolism in neonates.

Brain sterols in the AY-9944 rat model of atypical absence seizures.

Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens.

Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial.

Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.

Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women.

Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality.

Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3.

Whole-body utilization of n-3 PUFA in n-6 PUFA-deficient rats.

Why is carbon from some polyunsaturates extensively recycled into lipid synthesis?

Survival of the fattest: fat babies were the key to evolution of the large human brain.

Problems with essential fatty acids: time for a new paradigm?

Dietary alpha-linolenic acid increases the n-3 PUFA content of sow's milk and the tissues of the suckling piglet.

Metabolism of polyunsaturated fatty acids and ketogenesis: an emerging connection.

Intramuscular injection of antigens and adjuvant preferentially decreases 18:2n-6 and 18:3n-3 in pig neck muscle.

Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols.

Claims to identify detrimental effects of the ketogenic diet (KD) on cognitive function in rats.

Dietary 18:3omega3 influences immune function and the tissue fatty acid response to antigens and adjuvant.

Effects of a diet high in plant sterols, vegetable proteins, and viscous fibers (dietary portfolio) on circulating sterol levels and red cell fragility in hypercholesterolemic subjects.

Origins and evolution of the Western diet: implications of iodine and seafood intakes for the human brain.

Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats.

Breath acetone predicts plasma ketone bodies in children with epilepsy on a ketogenic diet.

Suckling rats actively recycle carbon from alpha-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates.

[Survival of the fattest: the key to human brain evolution].

Omega-3 fatty acids, energy substrates, and brain function during aging.

Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate.

Comparison of composition and absorption of sugarcane policosanols.

alpha-Linolenic acid and fish oil n-3 fatty acids and cardiovascular disease risk.

Docosahexaenoic acid and human brain evolution: missing the forest for the trees--comments by Cunnane.

Biosynthetic production of universally (13)C-labelled polyunsaturated fatty acids as reference materials for natural health product research.

Automated synthesis of 11C-acetoacetic acid, a key alternate brain fuel to glucose.

Docosahexaenoic acid and shore-based diets in hominin encephalization: a rebuttal.

Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements.

Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial.

Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease.

Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis.

An emerging risk factor for obesity: does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development?

[11C] acetoacetate utilization by breast and prostate tumors: a PET and biodistribution study in mice.

Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial.

Conjugated linoleic acids: why the discrepancy between animal and human studies?

Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly.

Heterogeneity in randomized controlled trials of long chain (fish) omega-3 fatty acids in restenosis, secondary prevention and ventricular arrhythmias.

Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly.

Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate.

Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids.

alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans.

n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations.

Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men.

Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring.

Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects.

Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain.

Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects.

Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly.

n-3 fatty acids and cardiovascular events.

Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats.

Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease.

Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?

n-3 PUFA status affects expression of genes involved in neuroenergetics differently in the fronto-parietal cortex compared to the CA1 area of the hippocampus: effect of rest and neuronal activation in the rat.

Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition.

Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.

Thyroid function and cognition in the euthyroid elderly: A case-control study embedded in Quebec longitudinal study - NuAge.

Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study.

Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype.

Long-term calorie restriction has minimal impact on brain metabolite and fatty acid profiles in aged rats on a Western-style diet.

Brain Docosahexaenoic Acid [DHA] Incorporation and Blood Flow Are Increased in Chronic Alcoholics: A Positron Emission Tomography Study Corrected for Cerebral Atrophy.

Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline.