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The value of preserving HIV-specific immune responses.
Journal of HIV therapy Feb, 2003 | Pubmed ID: 12840711
Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Journal of virology May, 2004 | Pubmed ID: 15078927
Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.
AIDS research and human retroviruses Mar, 2004 | Pubmed ID: 15117455
Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells.
Journal of virology Aug, 2004 | Pubmed ID: 15280492
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
The Journal of experimental medicine Sep, 2004 | Pubmed ID: 15381726
Limited durability of viral control following treated acute HIV infection.
PLoS medicine Nov, 2004 | Pubmed ID: 15526059
Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection.
Blood Sep, 2005 | Pubmed ID: 15905189
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Journal of virology Nov, 2005 | Pubmed ID: 16227247
Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.
Blood Mar, 2006 | Pubmed ID: 16249391
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Nature Sep, 2006 | Pubmed ID: 16921384
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
Journal of virology Oct, 2006 | Pubmed ID: 17005693
Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection.
PLoS medicine Dec, 2006 | Pubmed ID: 17194190
Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.
Journal of virology May, 2007 | Pubmed ID: 17329344
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Nature immunology Nov, 2007 | Pubmed ID: 17906628
Increased sequence diversity coverage improves detection of HIV-specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2007 | Pubmed ID: 17982054
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.
The Journal of infectious diseases Feb, 2008 | Pubmed ID: 18275276
In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection.
PloS one , 2009 | Pubmed ID: 19165342
Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
PloS one , 2009 | Pubmed ID: 19352428
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.
Blood Jul, 2009 | Pubmed ID: 19365081
Treatment interruption to boost specific HIV immunity in acute infection.
Current opinion in HIV and AIDS Jan, 2007 | Pubmed ID: 19372861
Programmed death-1 as a factor in immune exhaustion and activation in HIV infection.
Current opinion in HIV and AIDS May, 2008 | Pubmed ID: 19372991
PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention.
Journal of immunology (Baltimore, Md. : 1950) May, 2009 | Pubmed ID: 19414738
Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2010 | Pubmed ID: 19949078
Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences.
The Journal of experimental medicine Jan, 2010 | Pubmed ID: 20065065
Impaired replication capacity of acute/early viruses in persons who become HIV controllers.
Journal of virology Aug, 2010 | Pubmed ID: 20504921
Protective and detrimental roles of IL-10 in HIV pathogenesis.
European cytokine network Sep, 2010 | Pubmed ID: 20732847
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
Nature medicine Oct, 2010 | Pubmed ID: 20890291
Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10.
Journal of leukocyte biology Apr, 2011 | Pubmed ID: 21097698
Ets-1 maintains IL-7 receptor expression in peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2011 | Pubmed ID: 21148801
Epithelial adhesion molecules can inhibit HIV-1-specific CD8⺠T-cell functions.
Blood May, 2011 | Pubmed ID: 21403126
HIV-specific CD4 T cells and immune control of viral replication.
Current opinion in HIV and AIDS May, 2011 | Pubmed ID: 21502921
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.
Blood Jul, 2011 | Pubmed ID: 21652684
High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.
Journal of virology Sep, 2011 | Pubmed ID: 21752903
HIV controllers: a multifactorial phenotype of spontaneous viral suppression.
Clinical immunology (Orlando, Fla.) Oct, 2011 | Pubmed ID: 21865089
Association of IL-10-promoter genetic variants with the rate of CD4 T-cell loss, IL-10 plasma levels, and breadth of cytotoxic T-cell lymphocyte response during chronic HIV-1 infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Jan, 2012 | Pubmed ID: 22100578
Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report.
Stem cells international , 2011 | Pubmed ID: 22190964
Role of PD-1 in HIV pathogenesis and as target for therapy.
Current HIV/AIDS reports Mar, 2012 | Pubmed ID: 22198819
Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
The Journal of infectious diseases May, 2012 | Pubmed ID: 22427677
CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes.
Journal of virology Jun, 2012 | Pubmed ID: 22496237
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
Nature immunology Jul, 2012 | Pubmed ID: 22683743
A Blueprint for HIV Vaccine Discovery.
Cell host & microbe Oct, 2012 | Pubmed ID: 23084910
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Blood Jan, 2013 | Pubmed ID: 23233659
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2013 | Pubmed ID: 23772031
Simultaneous TCR and CD244 Signals Induce Dynamic Downmodulation of CD244 on Human Antiviral T Cells.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2013 | Pubmed ID: 23913963
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