Daniel E. Kaufmann

The value of preserving HIV-specific immune responses.

Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.

Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.

Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells.

Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.

Limited durability of viral control following treated acute HIV infection.

Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection.

Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.

Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.

Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.

Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection.

Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.

Increased sequence diversity coverage improves detection of HIV-specific T cell responses.

Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection.

Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.

Treatment interruption to boost specific HIV immunity in acute infection.

Programmed death-1 as a factor in immune exhaustion and activation in HIV infection.

PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention.

Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.

Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences.

Impaired replication capacity of acute/early viruses in persons who become HIV controllers.

Protective and detrimental roles of IL-10 in HIV pathogenesis.

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.

Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10.

Ets-1 maintains IL-7 receptor expression in peripheral T cells.

Epithelial adhesion molecules can inhibit HIV-1-specific CD8⁺ T-cell functions.

HIV-specific CD4 T cells and immune control of viral replication.

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.

High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.

HIV controllers: a multifactorial phenotype of spontaneous viral suppression.

Association of IL-10-promoter genetic variants with the rate of CD4 T-cell loss, IL-10 plasma levels, and breadth of cytotoxic T-cell lymphocyte response during chronic HIV-1 infection.

Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report.

Role of PD-1 in HIV pathogenesis and as target for therapy.

Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.

CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes.

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.

A Blueprint for HIV Vaccine Discovery.

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.

Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.

Simultaneous TCR and CD244 Signals Induce Dynamic Downmodulation of CD244 on Human Antiviral T Cells.