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Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells.
The international journal of biochemistry & cell biology Nov, 2002 | Pubmed ID: 12200033
Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion.
Oncogene Sep, 2002 | Pubmed ID: 12214273
Human epithelial cell immortalization as a step in carcinogenesis.
Cancer letters May, 2003 | Pubmed ID: 12757978
Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines.
Oncogene Aug, 2003 | Pubmed ID: 12917625
Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells.
Oncogene May, 2005 | Pubmed ID: 15735711
Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter.
Molecular and cellular biology May, 2005 | Pubmed ID: 15870267
Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models.
Aging cell Aug, 2005 | Pubmed ID: 16026336
ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.
Molecular cancer research : MCR Sep, 2006 | Pubmed ID: 16966434
Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized.
Molecular cancer , 2007 | Pubmed ID: 17233903
Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis.
Cell cycle (Georgetown, Tex.) Aug, 2007 | Pubmed ID: 17671422
Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation.
Radiation research Jul, 2008 | Pubmed ID: 18582160
Cell type-specific DNA methylation patterns in the human breast.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2008 | Pubmed ID: 18780791
Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization.
Cancer research Jun, 2009 | Pubmed ID: 19509227
Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells.
Cancer research Oct, 2009 | Pubmed ID: 19773443
Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments.
Integrative biology : quantitative biosciences from nano to macro Jan, 2009 | Pubmed ID: 20023793
Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.
PloS one , 2010 | Pubmed ID: 20084174
Primary cilium-dependent and -independent Hedgehog signaling inhibits p16(INK4A).
Molecular cell Nov, 2010 | Pubmed ID: 21095584
Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2011 | Pubmed ID: 21300877
Epigenetic regulation of normal human mammary cell type-specific miRNAs.
Genome research Dec, 2011 | Pubmed ID: 21873453
Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia.
Cancer research Jul, 2012 | Pubmed ID: 22552289