High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying CompoundsEliza Guti *1,2, Ákos Máté Bede *1,3, Csongor Váróczy *1,3, Csaba Hegedűs 1, Máté Á. Demény 1,4, László Virág 1,4
1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 2Doctoral School of Molecular Medicine, University of Debrecen, 3National Academy of Scientist Education, University of Debrecen, 4ELKH-DE Cell Biology and Signaling Research Group
This protocol presents an automated, image-based high-throughput technique to identify compounds modulating natural killer cell-mediated breast cancer cell killing in the presence of a therapeutic anti-HER-2 antibody.
