Dynamic42 GmbH
2 ARTICLES PUBLISHED IN JoVE
Immunology and Infection
Immunocompetent Alveolus-on-Chip Model for Studying Alveolar Mucosal Immune Responses
Hristina Koceva 1, Mona Amiratashani 1, Knut Rennert 2, Alexander S. Mosig 1,3,4
1Institute of Biochemistry II, Jena University Hospital, 2Dynamic42 GmbH, 3Center for Sepsis Control and Care, Jena University Hospital, 4Jena School of Microbial Communication, Friedrich Schiller University Jena
Lung-on-chip models surpass traditional 2D cultures by mimicking the air-liquid interface and endothelial cell perfusion, simulating blood flow and nutrient exchange crucial for lung physiology studies. This enhances lung research relevance, offering a dynamic, physiologically accurate environment to advance the understanding and treatment of respiratory infections.
Immunology and Infection
Immunocompetent Intestine-on-Chip Model for Analyzing Gut Mucosal Immune Responses
Adrian Feile *1,2,3, Valentin D. Wegner *1, Martin Raasch 4, Alexander S. Mosig 1,2,3,5
1Institute of Biochemistry II, Jena University Hospital, 2Cluster of Excellence Balance of the Microverse, Friedrich Schiller University, 3Jena School of Microbial Communication, Friedrich Schiller University, 4Dynamic42 GmbH, 5Jena Center for Sepsis Control and Care, Jena University Hospital
Our detailed protocol outlines the creation and use of the advanced intestine-on-chip model, which simulates human intestinal mucosa with 3D structures and various cell types, enabling in-depth analysis of immune responses and cellular functions in response to microbial colonization.
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