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Dynamic42 GmbH

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Immunocompetent Alveolus-on-Chip Model for Studying Alveolar Mucosal Immune Responses

Hristina Koceva¹, Mona Amiratashani¹, Knut Rennert², Alexander S. Mosig^1,3,4

¹Institute of Biochemistry II, Jena University Hospital, ²Dynamic42 GmbH, ³Center for Sepsis Control and Care, Jena University Hospital, ⁴Jena School of Microbial Communication, Friedrich Schiller University Jena

Lung-on-chip models surpass traditional 2D cultures by mimicking the air-liquid interface and endothelial cell perfusion, simulating blood flow and nutrient exchange crucial for lung physiology studies. This enhances lung research relevance, offering a dynamic, physiologically accurate environment to advance the understanding and treatment of respiratory infections.

Immunology and Infection

Immunocompetent Intestine-on-Chip Model for Analyzing Gut Mucosal Immune Responses

Adrian Feile^*1,2,3, Valentin D. Wegner^*1, Martin Raasch⁴, Alexander S. Mosig^1,2,3,5

¹Institute of Biochemistry II, Jena University Hospital, ²Cluster of Excellence Balance of the Microverse, Friedrich Schiller University, ³Jena School of Microbial Communication, Friedrich Schiller University, ⁴Dynamic42 GmbH, ⁵Jena Center for Sepsis Control and Care, Jena University Hospital

Our detailed protocol outlines the creation and use of the advanced intestine-on-chip model, which simulates human intestinal mucosa with 3D structures and various cell types, enabling in-depth analysis of immune responses and cellular functions in response to microbial colonization.