Department of Diagnosis and Surgery - São Paulo State University (UNESP), School of Dentistry, Araraquara

1 ARTICLES PUBLISHED IN JoVE

Cancer Research

Alternative Strategy to Analyze In Vitro Cell Invasion of 3D Cultures

Natalie Ap. Rodrigues Fernandes¹, Camyla Rodrigues Nascimento¹, Laura Andrea González Maldonado^1,2, Carlos Rossa Junior¹

¹Department of Diagnosis and Surgery - São Paulo State University (UNESP), School of Dentistry, Araraquara, ²Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan

Invasion is a major biological phenomenon in the development and progression of cancer. This process is influenced by non-neoplastic cells and components of the tumor microenvironment. The purpose of this study is to describe an alternative method for analyzing tumor cell invasion in vitro using three-dimensional (3D) cultures.