the Affiliated Hospital to Changchun University of Chinese Medicine
2 ARTICLES PUBLISHED IN JoVE
Medicine
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Fan Li 1, Chengji Cui 2, Haiyan Yu 3, Chunguang Yi 3, Guang Ta 4, Jie Wang 1, Xu Huang 2, Yutong Liu 3, Shoulin Zhang 3
1College of Integrated Chinese and Western Medicine, Changchun University of Chinese Medicine, 2Nephropathy Department, the Affiliated Hospital to Changchun University of Chinese Medicine, 3College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 4Internal Medicine Intensive Care Unit, the Affiliated Hospital to Changchun University of Chinese Medicine
The present protocol describes the establishment of a membranous nephropathy (MN) animal model, and how Kemeng Fang's inhibition reduces MN rat podocyte apoptosis by activating the PI3K/AKT signaling pathway.
Medicine
Evaluating Salidroside as a Therapeutic Agent for Vascular Calcification Using Network Pharmacology and Experimental Rat Models
Han-Ying Xu *1, Xiao-Lei Tang *2, Peng-Fei Li 3, Dong-Mei Zhang 4, Guang Ta 5, Jing Lu 2, Jian Wang 1
1Department of Encephalopathy, The Affiliated Hospital of Changchun University of Chinese Medicine, 2Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, 3Department of Nephrology, The Affiliated Hospital to Changchun University of Chinese Medicine, 4Scientific Research Office, The Affiliated Hospital to Changchun University of Chinese Medicine, 5Rehabilitation Department, The Affiliated hospital to Changchun University of Chinese Medicine
This study establishes a rat model of vascular calcification induced by a high-fat diet (HFD) combined with vitamin D3 (VD3). The model was used to evaluate the therapeutic efficacy of salidroside in preventing and treating vascular calcification, providing insights into its potential mechanisms of action through network pharmacology and in vivo experiments.
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