the Affiliated Hospital to Changchun University of Chinese Medicine

2 ARTICLES PUBLISHED IN JoVE

Medicine

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Fan Li¹, Chengji Cui², Haiyan Yu³, Chunguang Yi³, Guang Ta⁴, Jie Wang¹, Xu Huang², Yutong Liu³, Shoulin Zhang³

¹College of Integrated Chinese and Western Medicine, Changchun University of Chinese Medicine, ²Nephropathy Department, the Affiliated Hospital to Changchun University of Chinese Medicine, ³College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, ⁴Internal Medicine Intensive Care Unit, the Affiliated Hospital to Changchun University of Chinese Medicine

The present protocol describes the establishment of a membranous nephropathy (MN) animal model, and how Kemeng Fang's inhibition reduces MN rat podocyte apoptosis by activating the PI3K/AKT signaling pathway.

Medicine

Evaluating Salidroside as a Therapeutic Agent for Vascular Calcification Using Network Pharmacology and Experimental Rat Models

Han-Ying Xu^*1, Xiao-Lei Tang^*2, Peng-Fei Li³, Dong-Mei Zhang⁴, Guang Ta⁵, Jing Lu², Jian Wang¹

¹Department of Encephalopathy, The Affiliated Hospital of Changchun University of Chinese Medicine, ²Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, ³Department of Nephrology, The Affiliated Hospital to Changchun University of Chinese Medicine, ⁴Scientific Research Office, The Affiliated Hospital to Changchun University of Chinese Medicine, ⁵Rehabilitation Department, The Affiliated hospital to Changchun University of Chinese Medicine

This study establishes a rat model of vascular calcification induced by a high-fat diet (HFD) combined with vitamin D3 (VD3). The model was used to evaluate the therapeutic efficacy of salidroside in preventing and treating vascular calcification, providing insights into its potential mechanisms of action through network pharmacology and in vivo experiments.