Schoen Clinic Bad Aibling

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Michail Georgopoulos¹, Angelos Pavlopoulos¹, Nefeli Zerva¹, Asterios Kokkonakis¹, Iordanis Mourouzis¹, Nikolaus Plesnila², Constantinos Pantos¹, Athanasios Lourbopoulos^1,2,3

¹Department of Pharmacology Medical School of Athens, National and Kapodistrian University of Athens, ²Institute for Stroke and Dementia Research (ISD), University of Munich Medical Center, ³Department of Neurointensive Care, Schoen Clinic Bad Aibling

This article presents a protocol for executing the highly translational and independently proven mouse Stroke Unit (mSU) concept in large-stroke mice. It also provides a standardized protocol for executing the focal experimental stroke scale in mice, which evaluates stroke focal deficits detected even long-term.