Identification of Ferroptosis- and Hypoxia-related Genes in iPSC-derived Oligodendrocyte Precursor Cells from Multiple Sclerosis PatientsXia Zhang *1, Yuming Wang *2, Ruifang Sui 1, Yong Zhong 1, Ping Yi 2
1Department of Ophthalmology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, 2Department of Spine Surgery, China-Japan Friendship Hospital
This study provides novel insights into the interactions among hypoxia, ferroptosis, and immune infiltration in the pathogenesis of multiple sclerosis (MS) via bioinformatics analysis. By employing weighted gene coexpression network analysis (WGCNA) and protein-protein interaction (PPI) analysis, we identified three pivotal hub genes (ITGB1, ITGB8, and VIM).
