Chinese Academy of Medical Sciences and Peking Union Medical College Hospital

1 ARTICLES PUBLISHED IN JoVE

Medicine

Identification of Ferroptosis- and Hypoxia-related Genes in iPSC-derived Oligodendrocyte Precursor Cells from Multiple Sclerosis Patients

Xia Zhang^*1, Yuming Wang^*2, Ruifang Sui¹, Yong Zhong¹, Ping Yi²

¹Department of Ophthalmology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, ²Department of Spine Surgery, China-Japan Friendship Hospital

This study provides novel insights into the interactions among hypoxia, ferroptosis, and immune infiltration in the pathogenesis of multiple sclerosis (MS) via bioinformatics analysis. By employing weighted gene coexpression network analysis (WGCNA) and protein-protein interaction (PPI) analysis, we identified three pivotal hub genes (ITGB1, ITGB8, and VIM).