Karmanos Cancer Institute

1 ARTICLES PUBLISHED IN JoVE

Cancer Research

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

Terrence Wong¹, Roslyn Tedja², Hussein Chehade², Robert Morris¹, Ayesha B. Alvero², Gil Mor²

¹Department of Gynecologic Oncology, Karmanos Cancer Institute, ²C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University School of Medicine

This protocol describes the establishment of a three-dimensional (3D) ex vivo model of cancer cell-omentum interaction. The model provides a platform for elucidating pro-tumor mechanisms within the adipose niche and for testing novel therapies.