Akonni Biosystems, Inc.
2 ARTICLES PUBLISHED IN JoVE
JoVE Journal
High-throughput, Automated Extraction of DNA and RNA from Clinical Samples using TruTip Technology on Common Liquid Handling Robots
Rebecca C. Holmberg 1, Alissa Gindlesperger 1, Tinsley Stokes 1, Dane Brady 2, Nitu Thakore 3, Philip Belgrader 3, Christopher G. Cooney 3, Darrell P. Chandler 4
1Application Development, Akonni Biosystems, Inc., 2Manufacturing, Akonni Biosystems, Inc., 3Engineering, Akonni Biosystems, Inc., 4Research & Development, Akonni Biosystems, Inc.
TruTip is a simple nucleic acid extraction technology whereby a porous, monolithic binding matrix is inserted into a pipette tip. Consequently, the sample preparation format is compatible with most liquid handling instruments, and can be used for many medium to high-throughput clinical applications and sample types.
Immunology and Infection
Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Yvonne Linger 1, Alexander Kukhtin 1, Julia Golova 1, Alexander Perov 1, Peter Qu 1, Christopher Knickerbocker 1, Christopher G. Cooney 1, Darrell P. Chandler 1
1Akonni Biosystems, Inc.
An amplification microarray combines asymmetric PCR amplification and microarray hybridization into a single chamber, which significantly streamlines microarray workflow for the end user. Simplifying microarray workflow is a necessary first step for creating microarray-based diagnostics that can be routinely used in lower-resource environments.
