University of Nebraska at Lincoln

1 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Protein Misfolding Cyclic Amplification of Prions

Samuel E. Saunders¹, Jason C. Bartz², Ronald A. Shikiya²

¹Department of Civil Engineering, University of Nebraska at Lincoln, ²Department of Medical Microbiology and Immunology, Creighton University

Protein misfolding cyclic amplification (PMCA) is an in vitro assay for the study of prion conversion and strain and species barriers. It can also be used as a prion detection assay.