Canadian Blood Services
2 ARTICLES PUBLISHED IN JoVE
Immunology and Infection
Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis
Tik Nga Tong 1, Donald R. Branch 1,2
1Department of Laboratory Medicine and Pathobiology, University of Toronto, 2Centre for Innovation, Canadian Blood Services
The monocyte monolayer assay (MMA) is an in vitro assay that utilizes isolated primary monocytes obtained from mammalian peripheral whole blood to evaluate Fcγ receptor (FcγR)-mediated phagocytosis.
Medicine
Routine Screening Method for Microparticles in Platelet Transfusions
Daniel Millar 1, Larry Murphy 2, Audrey Labrie 1, Elisabeth Maurer-Spurej 1,3,4
1Research & Development, LightIntegra Technology Inc., 2Quality Engineering & Regulatory, LightIntegra Technology Inc., 3Department of Pathology and Laboratory Medicine; Center for Blood Research, University of British Columbia, 4Canadian Blood Services
Platelet inventory management based on screening microparticle content in platelet concentrates is a new quality improvement initiative in hospital blood banks. The goal is to differentiate activated from non-activated platelets to optimize the use of platelets. Providing non-activated platelets to hematology-oncology patients might reduce their high risk to become refractory.
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