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Canadian Blood Services

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis

¹Department of Laboratory Medicine and Pathobiology, University of Toronto, ²Centre for Innovation, Canadian Blood Services

The monocyte monolayer assay (MMA) is an in vitro assay that utilizes isolated primary monocytes obtained from mammalian peripheral whole blood to evaluate Fcγ receptor (FcγR)-mediated phagocytosis.

Medicine

Routine Screening Method for Microparticles in Platelet Transfusions

Daniel Millar¹, Larry Murphy², Audrey Labrie¹, Elisabeth Maurer-Spurej^1,3,4

¹Research & Development, LightIntegra Technology Inc., ²Quality Engineering & Regulatory, LightIntegra Technology Inc., ³Department of Pathology and Laboratory Medicine; Center for Blood Research, University of British Columbia, ⁴Canadian Blood Services

Platelet inventory management based on screening microparticle content in platelet concentrates is a new quality improvement initiative in hospital blood banks. The goal is to differentiate activated from non-activated platelets to optimize the use of platelets. Providing non-activated platelets to hematology-oncology patients might reduce their high risk to become refractory.