Catholic Kwandong University College of Medicine

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Jae-Gyun Choi^*1, Dong-Wook Kang^*1, Jaehyuk Kim¹, Miae Lee¹, Sheu-Ran Choi², Jin Bong Park¹, Hyun-Woo Kim¹

¹Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, ²Department of Pharmacology, Catholic Kwandong University College of Medicine

A transient scald injury (65 °C ± 0.5 °C, 3 s) of one hind paw decreases the threshold (g) to von Frey filament stimulation of the ipsilateral side and alters gait pattern. Besides, burn injury induces depression-like behavior in the forced swimming test.