The University of Chicago Medical Center
2 ARTICLES PUBLISHED IN JoVE
Neuroscience
Strategies for Study of Neuroprotection from Cold-preconditioning
Heidi M. Mitchell 1, David M. White 1, Richard P. Kraig 1
1Department of Neurology, The University of Chicago Medical Center
We seek to define the neural immune signaling responsible for cold-preconditioning as means to identify novel targets for therapeutics development to protect brain before injury onset. We present strategies for such work that require biological systems, experimental manipulations plus technical capacities that are highly reproducible and sensitive.
Neuroscience
Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
Aya D. Pusic *1, Yelena Y. Grinberg *1, Heidi M. Mitchell 2, Richard P. Kraig 1
1Department of Neurology and Committee on Neurobiology, The University of Chicago Medical Center, 2Department of Neurology, The University of Chicago Medical Center
Migraine and its transformation to chronic migraine are immense healthcare burdens in need of improved treatment options. We seek to define how neural immune signaling modulates the susceptibility to migraine, modeled in vitro using spreading depression in hippocampal slice cultures, as a means to develop novel therapeutic targets.
