The University of Chicago Medical Center

2 ARTICLES PUBLISHED IN JoVE

Neuroscience

Strategies for Study of Neuroprotection from Cold-preconditioning

Heidi M. Mitchell¹, David M. White¹, Richard P. Kraig¹

¹Department of Neurology, The University of Chicago Medical Center

We seek to define the neural immune signaling responsible for cold-preconditioning as means to identify novel targets for therapeutics development to protect brain before injury onset. We present strategies for such work that require biological systems, experimental manipulations plus technical capacities that are highly reproducible and sensitive.

Neuroscience

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Aya D. Pusic^*1, Yelena Y. Grinberg^*1, Heidi M. Mitchell², Richard P. Kraig¹

¹Department of Neurology and Committee on Neurobiology, The University of Chicago Medical Center, ²Department of Neurology, The University of Chicago Medical Center

Migraine and its transformation to chronic migraine are immense healthcare burdens in need of improved treatment options. We seek to define how neural immune signaling modulates the susceptibility to migraine, modeled in vitro using spreading depression in hippocampal slice cultures, as a means to develop novel therapeutic targets.