University of Victoria
2 ARTICLES PUBLISHED IN JoVE
Neuroscience
Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
Anthony Renda 1, Raad Nashmi 1
1Department of Biology, University of Victoria
We have developed a novel technique of quantifying nicotinic acetylcholine receptor changes within subcellular regions of specific subtypes of CNS neurons to better understand the mechanisms of nicotine addiction by using a combination of approaches including fluorescent protein tagging of the receptor using the knock-in approach and spectral confocal imaging.
Bioengineering
Preparation of 3D Fibrin Scaffolds for Stem Cell Culture Applications
Kathleen Kolehmainen 1, Stephanie M. Willerth 2
1Department of Biology, University of Victoria , 2Department of Mechanical Engineering, Division of Medical Sciences, University of Victoria
This work details the preparation of 3D fibrin scaffolds for culturing and differentiating plutipotent stem cells. Such scaffolds can be used to screen the effects of various biological compounds on stem cell behavior as well as modified to contain drug delivery systems.
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