Queen's University
2 ARTICLES PUBLISHED IN JoVE
Biology
Mechanical Stimulation of Chondrocyte-agarose Hydrogels
James A. Kaupp 1, Joanna F. Weber 1, Stephen D. Waldman 1,2
1Department of Mechanical and Materials Engineering, Queen's University , 2Department of Chemical Engineering, Queen's University
The biosynthesis of cartilaginous extracellular matrix by chondrocytes can be affected by application of mechanical stimuli. This method describes the technique of applying dynamic compressive strains to chondrocytes encapsulated in 3D constructs and the evaluation of induced changes in chondrocyte metabolism.
Biology
C. elegans Chemotaxis Assay
Olivia Margie 1, Chris Palmer 2, Ian Chin-Sang 3
1Life Sciences, Queen's University , 2Department of Chemical Engineering, Queen's University , 3Department of Biology, Queen's University
A method of quantitatively evaluating the chemotactic response of Caenorhabditis elegans is described. A chemotactic index (CI) was employed as a way to precisely evaluate the response of worms to certain targets, and serve as a platform of comparison between strains and compounds of interest.
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