Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental DisordersGiovanni Provenzano 1, Luca Pangrazzi 1, Andrea Poli 2, Nicoletta Berardi 2, Yuri Bozzi 1,2
1Centre for Integrative Biology (CIBIO), University of Trento, 2CNR Neuroscience Institute, Pisa, Italy
We describe an immunohistochemistry protocol to study the profile of hippocampal neuron activation following exposure to a spatial learning task in a mouse model characterized by cognitive deficits of neurodevelopmental origin. This protocol can be applied to both genetic or pharmacological mouse models characterized by cognitive deficits.
