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CNR Neuroscience Institute, Pisa, Italy

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Giovanni Provenzano¹, Luca Pangrazzi¹, Andrea Poli², Nicoletta Berardi², Yuri Bozzi^1,2

¹Centre for Integrative Biology (CIBIO), University of Trento, ²CNR Neuroscience Institute, Pisa, Italy

We describe an immunohistochemistry protocol to study the profile of hippocampal neuron activation following exposure to a spatial learning task in a mouse model characterized by cognitive deficits of neurodevelopmental origin. This protocol can be applied to both genetic or pharmacological mouse models characterized by cognitive deficits.