INSERM, CNRS, UNIV Nantes, CHU Nantes
2 ARTICLES PUBLISHED IN JoVE
Medicine
Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
Audrey Ayer 1, Frederic Borel 1, Francois Moreau 1, Xavier Prieur 1, Michel Neunlist 2, Bertrand Cariou 3, Claire Blanchard *1,4, Cedric Le May *1
1l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, 2CHU Nantes, Institut des Maladies de l'Appareil Digestif, INSERM U913, 3l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, 4Service de Clinique Chirurgicale Digestive et Endocrinienne, CHU de Nantes
Bariatric surgery is the most efficient way to reduce body weight and the deadly metabolic complications (diabetes, obesity, and dyslipidemia) frequently associated with morbid obesity. Mouse models of bariatric surgery represent a unique asset for deciphering molecular mechanisms behind the beneficial effects of these surgeries on diabetes, hypertension, and dyslipidemia.
Medicine
Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice
Samuel Frey 1,2, Audrey Ayer 1, Thibaud Sotin 1, Victoria Lorant 1, Bertrand Cariou 1, Claire Blanchard *1,2, Cédric Le May *1
1CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes Université, 2Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Hôtel Dieu, CHU Nantes
Single-anastomosis duodeno-ileal bypass (SADI-S) is an emerging bariatric procedure with important metabolic effects. In this article, we present a reliable and reproducible model of SADI-S in mice.
