Medical Research Council Laboratory of Molecular Biology

1 ARTICLES PUBLISHED IN JoVE

Chemistry

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Benjamí Oller-Salvia¹

¹Medical Research Council Laboratory of Molecular Biology

Incorporating a cyclopropene derivative of lysine into antibodies allows the site-specific, rapid and efficient linkage of tetrazine-bearing molecules to generate antibody-drug conjugates.