Environmental and Occupational Health Sciences Institute
2 ARTICLES PUBLISHED IN JoVE
Biology
Whole-Body Nanoparticle Aerosol Inhalation Exposures
Jinghai Yi 1,2, Bean T. Chen 3, Diane Schwegler-Berry 3, Dave Frazer 3, Vince Castranova 3, Carroll McBride 1, Travis L. Knuckles 1,2, Phoebe A. Stapleton 1,2, Valerie C. Minarchick 1,2, Timothy R. Nurkiewicz 1,2
1Department of Physiology and Pharmacology, School of Medicine, West Virginia University , 2Center for Cardiovascular and Respiratory Sciences, West Virginia University , 3National Institute for Occupational Safety and Health
A whole-body nanoparticle aerosol inhalation exposure facility was constructed for nano-sized titanium dioxide (TiO2) inhalation toxicology studies. This system provides nano-TiO2 aerosol test atmospheres that have: 1) a steady mass concentration; 2) a homogenous composition free of contaminants; and 3) a stable particle size distribution during aerosol generation.
Developmental Biology
Ex Vivo Perfusion of the Rodent Placenta
Jeanine N. D'Errico 1, Sara B. Fournier 2, Phoebe A. Stapleton 1,2
1Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 2Environmental and Occupational Health Sciences Institute
Here is presented a protocol of ex vivo maternal-fetal vascular perfusion to enable the administration of a test article into maternal vasculature and to evaluate placental transfer of xenobiotic particles or pharmacological agents in addition to alterations in placental physiology.
