Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine ModelRami Ahmad Shahror 1,2,3, Chung-Che Wu 2,3,4,5, Yung-Hsiao Chiang 1,2,3,4,5, Kai-Yun Chen 1,2,3
1Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, 2Center for Neurotrauma and Neuroregeneration, Taipei Medical University, 3TMU Neuroscience Research Center, Taipei Medical University, 4Department of Neurosurgery, Taipei Medical University Hospital, 5Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University
Presented here is a protocol for non-invasive mesenchymal stem cell (MSC) delivery and tracking in a mouse model of traumatic brain injury. Superparamagnetic iron oxide nanoparticles are employed as a magnetic resonance imaging (MRI) probe for MSC labeling and non-invasive in vivo tracking following intranasal delivery using real-time MRI.
