Accedi

Taipei Medical University and National Health Research Institutes

1 ARTICLES PUBLISHED IN JoVE

Medicine

Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model

Rami Ahmad Shahror^1,2,3, Chung-Che Wu^2,3,4,5, Yung-Hsiao Chiang^1,2,3,4,5, Kai-Yun Chen^1,2,3

¹Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, ²Center for Neurotrauma and Neuroregeneration, Taipei Medical University, ³TMU Neuroscience Research Center, Taipei Medical University, ⁴Department of Neurosurgery, Taipei Medical University Hospital, ⁵Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University

Presented here is a protocol for non-invasive mesenchymal stem cell (MSC) delivery and tracking in a mouse model of traumatic brain injury. Superparamagnetic iron oxide nanoparticles are employed as a magnetic resonance imaging (MRI) probe for MSC labeling and non-invasive in vivo tracking following intranasal delivery using real-time MRI.