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Pfizer Worldwide Research and Development

3 ARTICLES PUBLISHED IN JoVE

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Cancer Research

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Shuang Chen 1, Andreas Giannakou 1, Jonathon Golas 1, Kenneth G. Geles 1
1Oncology R&D group, Pfizer Worldwide Research and Development

An in vitro model system was developed to capture tissue architectural changes during lung squamous carcinoma (LUSC) progression in a 3-dimensional (3D) co-culture with cancer-associated fibroblasts (CAFs). This organoid system provides a unique platform to investigate the roles of diverse tumor cell-intrinsic and extrinsic changes that modulate the tumor phenotype.

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Medicine

Application of Straight-needle, Three-tailed, Knot-free, Peritoneal Sutures in Laparoscopic Transabdominal Preperitoneal Hernia Repair
Ning Ma *1, Zhen Zong *2, Fu-xing Tang 1, En-min Huang 1, Tao Ma 1, Wei-sheng Yang 1, Jia-lin Chen 1, Shuang Chen 1, Tai-cheng Zhou 1
1Department of Gastroenterological Surgery and Hernia Center, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, 2Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Nanchang University

Here, we present a protocol to introduce a new peritoneal suture method. This method is called straight-needle, three-tailed, knot-free suture, and we will outline the manufacturing method and clinical application of this suture in detail.

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Medicine

Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair
Ning Ma *1, Dai Tang *2, Fu-xing Tang 1, En-min Huang 1, Tao Ma 1, Wei-sheng Yang 1, Chuang-xiong Liu 1, Hao-nan Huang 1, Shuang Chen 1, Tai-cheng Zhou 1
1Department of Gastroenterological Surgery and Hernia Center, The Sixth Affiliated Hospital, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, Sun Yat-sen University, 2Department of Gastrointestinal Surgery, the Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi)

Presented here is a method for improving the mesh placement in laparoscopic incisional hernia repair, which can shorten the time required for mesh fixation and reduce the occurrence of postoperative chronic pain.

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