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UCL Queen Square Institute of Neurology, Queen Square House

3 ARTICLES PUBLISHED IN JoVE

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Neuroscience

CMAP Scan MUNE (MScan) - A Novel Motor Unit Number Estimation (MUNE) Method
Anna B. Jacobsen 1, Hugh Bostock 2, Hatice Tankisi 1
1Department of Clinical Neurophysiology, Aarhus University Hospital, 2Institute of Neurology, Queen Square House

This protocol describes a new method to estimate the number of functioning motor units in a muscle, by fitting a model to a detailed stimulus-response curve of the compound muscle action potential. It is quick and easy to perform and analyze and has excellent reproducibility.

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Neuroscience

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
Agnes Witt 1, Hugh Bostock 2, Werner J. Z'Graggen 3, S. Veronica Tan 4, Alexander Gramm Kristensen 1, Rikke Søgaard Kristensen 1, Lotte Hardbo Larsen 1, Zennia Zeppelin 1, Hatice Tankisi 1
1Department of Clinical Neurophysiology, Aarhus University Hospital, 2UCL Queen Square Institute of Neurology, Queen Square House, 3Departments of Neurology and Neurosurgery, Inselspital, Bern University Hospital, University of Bern, 4MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery

Presented here is a protocol for the recording of muscle velocity recovery cycles (MVRCs), a new method of examining muscle membrane properties. MVRCs enable in vivo assessment of muscle membrane potential and alterations in muscle ion channel function in relation to pathology, and it enables the demonstration of muscle depolarization in neurogenic muscles.

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Neuroscience

Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation
Hatice Tankisi 1, James Howells 2, Bülent Cengiz 3, Gintaute Samusyte 4, Martin Koltzenburg 5, Hugh Bostock 6
1Department of Clinical Neurophysiology, Aarhus University Hospital, 2Central Clinical School, Faculty of Medicine and Health, University of Sydney, 3Department of Neurology, Gazi University Faculty of Medicine, 4Department of Neurology, Medical Academy, Lithuanian University of Health Sciences, 5Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, 6Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology

We present a suite of standardized single- and paired-pulse transcranial magnetic stimulation (TMS) recording protocols, with options for conventional amplitude measurements and threshold-tracking. This program can control three different types of magnetic stimulators and is designed to enable all tests to be performed conveniently by a single operator.

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