Cancer Center Amsterdam

8 ARTICLES PUBLISHED IN JoVE

Medicine

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Alberto Balduzzi^*1,2, Maurice J. W. Zwart^*1, Rens M. A. Kempeneers¹, Marja A. Boermeester¹, Olivier R. Busch¹, Marc G. Besselink¹

¹Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, ²General and Pancreatic Surgery Department, Pancreas Institute, University and Hospital Trust of Verona

Robotic lateral pancreaticojejunostomy (RLPJ) may be used in patients with painful, morphine dependent, chronic pancreatitis and a dilated main pancreatic duct. We describe a standardized and reproducible technique for RLPJ, which includes transection of the gastroduodenal artery.

Medicine

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

Sanne Lof¹, Rushda Rajak², Frederique L. I. M. Vissers³, Maarten Korrel³, Adrian Bateman², Johanna Verheij⁴, Caroline Verbeke⁵, Ivana Cataldo⁶, Marc G. Besselink³, Mohammed Abu Hilal¹

¹Department of Surgery, Southampton University Hospital NHS Foundation Trust, ²Department of Pathology, Southampton University Hospital NHS Foundation Trust, ³Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, ⁴Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, ⁵Department of Pathology, Oslo University Hospital & University of Oslo, ⁶Department of Pathology, Ca Foncello Hospital

The current study highlights a standardized approach to the macroscopic assessment of distal pancreatectomy specimens for pancreatic ductal adenocarcinoma, with special emphasis on the measurement of pancreatic dimensions and those of other organs, inking of margins, measurement of tumor size and proximity to margins, lymph node sampling and block selection.

Neuroscience

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Rianne Haumann^*1,2, Elvin ’t Hart^*2, Marc P. P. Derieppe², Helena C. Besse³, Gertjan J. L. Kaspers^1,2, Eelco Hoving², Dannis G. van Vuurden^1,2, Esther Hulleman^1,2, Mario Ries³

¹Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology, Cancer Center Amsterdam, ²Princess Máxima Center for Pediatric Oncology, ³Imaging Division, Utrecht University

The blood-brain barrier (BBB) can be temporarily disrupted with microbubble-mediated focused ultrasound (FUS). Here, we describe a step-by-step protocol for high-throughput BBB opening in vivo using a modular FUS system accessible for non-ultrasound experts.

Medicine

Robotic Central Pancreatectomy with Roux-en-Y Pancreaticojejunostomy

Tess M.E. van Ramshorst¹, Maurice J.W. Zwart¹, Rogier P. Voermans², Sebastiaan Festen³, Freek Daams⁴, Olivier R. Busch¹, Matthijs W.N. Oomen⁵, Marc G. Besselink¹, ¹

¹Department of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, ²Department of Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, ³Department of Surgery, OLVG, ⁴Department of Surgery, Amsterdam UMC, Vrije Universiteit, ⁵Department of Pediatric Surgery, Amsterdam UMC, Emma Children's Hospital

Robotic central pancreatectomy may be used in selected patients in experienced centers. This protocol presents all steps and the feasibility of a robotic central pancreatectomy with Roux-en-Y pancreaticojejunostomy in a 16-year-old adolescent patient.

Cancer Research

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique

Maurice J. W. Zwart^*1,2, Leia R. Jones^*1,2,3, Melissa E. Hogg⁴, Johanna A. M. G. Tol^1,2, Mohammad Abu Hilal³, Freek Daams⁵, Sebastiaan Festen⁶, Olivier R. Busch^1,2, Marc G. Besselink^1,2,

¹Department of Surgery, Amsterdam, the Netherlands, Amsterdam UMC, location University of Amsterdam, ²Cancer Center Amsterdam, the Netherlands, ³Department of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, ⁴Department of Surgery, Northshore University Health System, ⁵Department of Surgery, Amsterdam UMC, Vrije Universiteit, Cancer Center Amsterdam, ⁶Department of Surgery, OLVG

Robotic pancreatoduodenctomy (RPD) has been highly standardized in recent years and may be used in selected patients with pancreatic head cancer, including those with a replaced right hepatic artery. This case report describes a standardized and reproducible technique for RPD, which includes the approach of the Dutch LAELAPS-3 training program to an aberrant vasculature.

Medicine

Robotic Left Hepatectomy using Indocyanine Green Fluorescence Imaging for an Intrahepatic Complex Biliary Cyst

Burak Görgec^1,2, Babs M. Zonderhuis^2,3, Marc G. Besselink^1,2, Joris Erdmann^1,2,3, Geert Kazemier^2,3, Rutger-Jan Swijnenburg^1,2,3

¹Department of Surgery, Amsterdam UMC, location University of Amsterdam, ²Cancer Center Amsterdam, ³Department of Surgery, Amsterdam UMC, location Vrije Universiteit

Robotic liver surgery has gained more acceptance as a feasible, safe, and effective procedure for the treatment of both benign and malignant indications. However, robotic left hepatectomy is still technically demanding. We describe our surgical technique of a robotic left hepatectomy using indocyanine green fluorescence imaging for a large biliary cyst.

Robotic Spleen-Preserving Distal Pancreatectomy: The Warshaw and Kimura Techniques

Evgenia Kotsifa^1,2,3, Sebastiaan Festen⁴, Olivier R. Busch^1,3, Marc G. Besselink^1,3, Freek Daams^2,3,

¹Department of Surgery, Amsterdam UMC, location University of Amsterdam, ²Department of Surgery, Amsterdam UMC, location Vrije Universiteit, ³Cancer Center Amsterdam, ⁴Department of Surgery, OLVG

Here, we present a step-by-step protocol of robotic spleen preserving distal pancreatectomy, with and without preserving the splenic vessels (i.e., the Kimura and Warshaw techniques, respectively).

Medicine

Robotic D3 Partial Duodenal Resection with Primary Side-to-Side Anastomosis

Roberto Maria Montorsi^1,2,3, Sofia Xenaki^1,2,4, Sebastiaan Festen⁵, Paul Fockens^2,6, Barbara A. J. Bastiaansen^2,6, Freek Daams^2,7, Olivier R. Busch^1,2, M. G. Besselink^1,2,

¹Amsterdam UMC, Department of Surgery, University of Amsterdam, ²Cancer Center Amsterdam, ³Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, ⁴Department of General Surgery, University Hospital of Heraklion Crete, ⁵Department of Surgery, OLVG, ⁶Amsterdam UMC, Department of Gastroenterology, University of Amsterdam, ⁷Amsterdam UMC, Department of Surgery, Vrije Universiteit

This protocol presents a case of a robotic partial duodenal resection with primary side-to-side duodeno-jejunal reconstruction in a patient with a 5 cm duodenal stenosis. This is done at the third duodenal segment (D3) after an endoscopic mucosal resection (EMR) for a duodenal polyp.