Institute for Pathology "Victor Babes"
2 ARTICLES PUBLISHED IN JoVE
Medicine
Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice
Adelina Curaj 1, Sakine Simsekyilmaz 1, Mareike Staudt 1, Elisa Liehn 1
1Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany
A highly reproducible model for myocardial infarction in mice with minimal invasive manipulations is described. The model can be easily performed, resulting in a high reproducibility and survival rate. Thus, the described model will reduce the number of required animals as requested by the 3R principle (Replacement, Refinement and Reduction).
Medicine
Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access
Anne Cornelissen *1, Roberta Florescu *1, Nicole Schaaps 1, Mamdouh Afify 1, Sakine Simsekyilmaz 1, Elisa Liehn *1,2,3, Felix Vogt *1
1Division of Cardiology, Angiology, and Critical Care, University Hospital RWTH Aachen, 2Department for Operative Intensive Medicine, University Hospital RWTH Aachen, 3Institute for Pathology "Victor Babes"
This protocol describes the implantation of human coronary stents into the abdominal aorta of rats with an apoE-/- background using a trans-femoral access. Compared with other animal models, murine models carry the advantages of high throughput, reproducibility, ease of handling and housing, and a broad availability of molecular markers.
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