A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke ModelYi-Min Kuo 1, Yu-Yo Sun 2, Chia-Yi Kuan 2
1Department of Anesthesiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, 2Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine
Traditional photothrombotic stroke (PTS) models mainly induce dense platelet aggregates of a high resistance to tissue plasminogen activator (tPA)-lytic treatment. Here a modified murine PTS model is introduced by co-injecting thrombin and photosensitive dye for photoactivation. The thrombin-enhanced PTS model produces mixed platelet:fibrin clots and is highly sensitive to tPA-thrombolysis.
