UConn School of Medicine

2 ARTICLES PUBLISHED IN JoVE

Neuroscience

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Mitch R. Paro^*1, Daylin Gamiotea Turro^*1, Michael Mcgonnigle¹, Ketan R. Bulsara², Rajkumar Verma¹

¹Department of Neuroscience, UConn School of Medicine, ²Division of Neurosurgery, UConn School of Medicine

The protocol aims to provide methods for encephalomyosynangiosis-grafting of a vascular temporalis muscle flap on the pial surface of ischemic brain tissue-for the treatment of non-moyamoya acute ischemic stroke. The approach's efficacy in increasing angiogenesis is evaluated using a transient middle cerebral artery occlusion model in mice.

Biology

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Marta Stetsiv^*1,2, Matthew Wan^*1, Shagun Prabhu¹, Rosa Guzzo^1,2, Archana Sanjay¹

¹Department of Orthopedic Surgery, UConn School of Medicine, ²Department of Neuroscience, UConn School of Medicine

The murine bone marrow injury model is a useful tool for studying postnatal osteogenesis through intramembranous ossification. This simplified surgical protocol describes the bone marrow ablation procedure for downstream assessment of new bone formation and cellular responses following injury.