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2 ARTICLES PUBLISHED IN JoVE

Cancer Research

Intraductal Delivery and X-ray Visualization of Ethanol-Based Ablative Solution for Prevention and Local Treatment of Breast Cancer in Mouse Models

Elizabeth Kenyon^1,2, Erin K. Zaluzec^1,3, Katherine Powell^1,2, Maximilian Volk^1,4, Shatadru Chakravarty^2,5, Jeremy Hix^2,6, Ripla Arora^7,8, Jennifer J. Westerhuis^9,10, Matti Kiupel¹¹, Erik M. Shapiro^2,6, Lorenzo F. Sempere^1,2

A method of intraductal injection of reagents for an ethanol-based ablative solution to the mouse mammary ductal tree for in vivo imaging and breast cancer prevention is described. Injection directly into the nipple opening allows for targeting mammary epithelial cells with minimal collateral tissue damage.

Cancer Research

X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models

Elizabeth Kenyon^1,2, Erin Zaluzec^1,3, Katherine Powell^1,2, Maximilian Volk^1,4, Shatadru Chakravarty^2,5, Jeremy Hix^2,6, Matti Kiupel⁷, Erik M. Shapiro², Lorenzo F. Sempere^1,2

¹Precision Health Program, Michigan State University, ²Department of Radiology, Michigan State University, ³Department of Pharmacology & Toxicology, Michigan State University, ⁴College of Osteopathic Medicine, Michigan State University, ⁵TechInsights Inc., ⁶IQ Advanced Molecular Imaging Facility, Michigan State University, ⁷Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University

A procedure for the delivery of a chemical ablative solution to the rat mammary ductal tree for image-guided preventive treatment of breast cancer is described. Mammary epithelial cells can be targeted with minimal collateral tissue damage through cannulation directly into the nipple opening and intraductal infusion of a 70% ethanol-based ablative solution.