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2 ARTICLES PUBLISHED IN JoVE
Cancer Research
Intraductal Delivery and X-ray Visualization of Ethanol-Based Ablative Solution for Prevention and Local Treatment of Breast Cancer in Mouse Models
Elizabeth Kenyon 1,2, Erin K. Zaluzec 1,3, Katherine Powell 1,2, Maximilian Volk 1,4, Shatadru Chakravarty 2,5, Jeremy Hix 2,6, Ripla Arora 7,8, Jennifer J. Westerhuis 9,10, Matti Kiupel 11, Erik M. Shapiro 2,6, Lorenzo F. Sempere 1,2
1Precision Health Program, Michigan State University, 2Department of Radiology, College of Human Medicine, Michigan State University, 3Department of Pharmacology & Toxicology, College of Veterinary Medicine, Michigan State University, 4College of Osteopathic Medicine, Michigan State University, 5Advanced Materials Characterization Laboratory/Materials Research Center, Missouri University of Science and Technology, 6Institute for Quantitative (IQ) Health Science and Engineering Advanced Molecular Imaging Facility, Michigan State University, 7Department of Obstetrics Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, 8Institute for Quantitative (IQ) Health Science and Engineering, Michigan State University, 9Van Andel Research Institute, 10Miltenyi Biotec, 11Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University
A method of intraductal injection of reagents for an ethanol-based ablative solution to the mouse mammary ductal tree for in vivo imaging and breast cancer prevention is described. Injection directly into the nipple opening allows for targeting mammary epithelial cells with minimal collateral tissue damage.
Cancer Research
X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models
Elizabeth Kenyon 1,2, Erin Zaluzec 1,3, Katherine Powell 1,2, Maximilian Volk 1,4, Shatadru Chakravarty 2,5, Jeremy Hix 2,6, Matti Kiupel 7, Erik M. Shapiro 2, Lorenzo F. Sempere 1,2
1Precision Health Program, Michigan State University, 2Department of Radiology, Michigan State University, 3Department of Pharmacology & Toxicology, Michigan State University, 4College of Osteopathic Medicine, Michigan State University, 5TechInsights Inc., 6IQ Advanced Molecular Imaging Facility, Michigan State University, 7Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University
A procedure for the delivery of a chemical ablative solution to the rat mammary ductal tree for image-guided preventive treatment of breast cancer is described. Mammary epithelial cells can be targeted with minimal collateral tissue damage through cannulation directly into the nipple opening and intraductal infusion of a 70% ethanol-based ablative solution.
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