Ajou University
2 ARTICLES PUBLISHED IN JoVE
Developmental Biology
Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
Jae H. Lee 1,2, Yong II Cho 5, Sung S. Choi 4, Hae-Won Kim 1,2, Churl K. Min 3, Sang J. Lee 5
1Department of Nanobiomedical Sciences and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, 2Insititute of Tissue Regeneration Engineering, Dankook University, 3Department of Biological Sciences, Ajou University, 4Department of Pharmacy, Sahmyook University, 5Department of Animal Biotechnology, Sahmyook University
The goal of this protocol is to describe a loss- and gain-of function method that is applicable to identify neogenin as a stage-specific receptor that leads to trophectoderm and inner cell mass differentiation in preimplantation mouse embryos.
Biology
A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model
Hyunhee Kim 1, Juwon Jeong 1, Changhan Lee 1
1Department of Biological Sciences, Ajou University
An in vivo physiological model of α-synuclein is required to study and understand the pathogenesis of Parkinson's disease. We describe a method to monitor the cytotoxicity and aggregate formation of α-synuclein using a humanized yeast model.
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