Establishment of the Lysolecithin-Induced Demyelination Mouse Model
2:23
Osmotic Pump Preparation
3:52
Osmotic Pump Implantation
4:48
Results: Effects of Osmotic Pump-Based Drug-Delivery in Mouse Model
5:43
Conclusion
副本
Osmotic pump is of great value to the research of myelin regeneration, especially for those drugs with a short half-life, poor blood-brain barrier permeability, and of various peripheral side effects. Osmotic pump can bypass the blood-brain barrie
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Demyelination takes place in multiple central nervous system diseases. A reliable in vivo drug delivery technique is necessary for remyelinating drug testing. This protocol describes an osmotic pump-based method that allows long-term drug delivery directly into the brain parenchyma and improves the drug bioavailability, with broad application in remyelination research.