Synthetic Biology Platform,
Wyss Institute for Biologically Inspired Engineering,
Synthetic Biology Platform, Wyss Institute for Biologically Inspired Engineering
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Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling.
Genetics Feb, 2002 | Pubmed ID: 11861547
Protein and RNA export from the nucleus.
Developmental cell Mar, 2002 | Pubmed ID: 11879632
The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress.
Molecular cell Mar, 2002 | Pubmed ID: 11931764
Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis.
Microbiology (Reading, England) Apr, 2002 | Pubmed ID: 11932453
Identifying proteins that affect mRNA localization in living cells.
Methods (San Diego, Calif.) Feb, 2002 | Pubmed ID: 12054891
Nuclear protein transport.
Methods in enzymology , 2002 | Pubmed ID: 12073370
Requirements for the nuclear export of the small ribosomal subunit.
Journal of cell science Jul, 2002 | Pubmed ID: 12082158
Retrovirus-delivered siRNA.
BMC biotechnology Aug, 2002 | Pubmed ID: 12199908
Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import.
Journal of virology Nov, 2002 | Pubmed ID: 12368302
Intron status and 3'-end formation control cotranscriptional export of mRNA.
Genes & development Nov, 2002 | Pubmed ID: 12414728
In situ analysis of spatial relationships between proteins of the nuclear pore complex.
Biophysical journal Dec, 2002 | Pubmed ID: 12496130
Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae.
The Journal of biological chemistry Mar, 2003 | Pubmed ID: 12514182
Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery.
Nature genetics Feb, 2003 | Pubmed ID: 12524544
A microbead-based system for identifying and characterizing RNA-protein interactions by flow cytometry.
Molecular & cellular proteomics : MCP Dec, 2002 | Pubmed ID: 12543929
Nuclear transport as a target for cell growth.
Drug discovery today Jan, 2003 | Pubmed ID: 12565010
Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex.
Molecular biology of the cell Mar, 2003 | Pubmed ID: 12631707
Analysis of RNA-protein interactions by flow cytometry.
Current opinion in molecular therapeutics Jun, 2003 | Pubmed ID: 12870432
Intracellular transport of human immunodeficiency virus type 1 integrase.
Journal of cell science Nov, 2003 | Pubmed ID: 13130095
A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2003 | Pubmed ID: 14557538
Small molecule modulation of the human chromatid decatenation checkpoint.
Chemistry & biology Dec, 2003 | Pubmed ID: 14700634
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.
Cancer cell Dec, 2003 | Pubmed ID: 14706338
Modulation of interprotomer relationships is important for activation of dimeric calcium-sensing receptor.
The Journal of biological chemistry Apr, 2004 | Pubmed ID: 14729680
Nuclear transport and cancer: from mechanism to intervention.
Nature reviews. Cancer Feb, 2004 | Pubmed ID: 14732865
Therapeutic potential of retroviral RNAi vectors.
Expert opinion on biological therapy Mar, 2004 | Pubmed ID: 15006726
Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.
The Journal of biological chemistry Jun, 2004 | Pubmed ID: 15067004
Guardian at the gate: preventing unspliced pre-mRNA export.
Trends in cell biology May, 2004 | Pubmed ID: 15130577
Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization.
Cell May, 2004 | Pubmed ID: 15137937
PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits.
The EMBO journal Jul, 2004 | Pubmed ID: 15175657
REF-ereeing the cytoplasmic fate of mRNA via nuclear export.
Developmental cell Jun, 2004 | Pubmed ID: 15177019
Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors.
Genes & development Aug, 2004 | Pubmed ID: 15314027
Human cell proteins and human immunodeficiency virus DNA integration.
Frontiers in bioscience : a journal and virtual library Sep, 2004 | Pubmed ID: 15353349
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.
The Journal of biological chemistry Nov, 2004 | Pubmed ID: 15371438
Genome-wide mRNA surveillance is coupled to mRNA export.
Genes & development Nov, 2004 | Pubmed ID: 15489286
Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication.
Journal of virology Dec, 2004 | Pubmed ID: 15542626
A systems view of mRNP biology.
Genes & development Dec, 2004 | Pubmed ID: 15574591
HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases.
Virology Jan, 2005 | Pubmed ID: 15582665
The psammaplysenes, specific inhibitors of FOXO1a nuclear export.
Journal of natural products Apr, 2005 | Pubmed ID: 15844952
Developmentally induced changes in transcriptional program alter spatial organization across chromosomes.
Genes & development May, 2005 | Pubmed ID: 15905407
Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites.
Structure (London, England : 1993) Jul, 2005 | Pubmed ID: 16004872
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.
Cell Jul, 2005 | Pubmed ID: 16009131
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
BMC developmental biology , 2005 | Pubmed ID: 16033648
Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells.
Genome biology , 2005 | Pubmed ID: 16086846
Multiple conformations in the ligand-binding site of the yeast nuclear pore-targeting domain of Nup116p.
The Journal of biological chemistry Oct, 2005 | Pubmed ID: 16105837
The uses of green fluorescent protein in yeasts.
Methods of biochemical analysis , 2006 | Pubmed ID: 16335714
Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication.
Virology Mar, 2006 | Pubmed ID: 16337983
Autoregulation of ribosome biosynthesis by a translational response in fission yeast.
Molecular and cellular biology Mar, 2006 | Pubmed ID: 16478994
Genomic association of the proteasome demonstrates overlapping gene regulatory activity with transcription factor substrates.
Molecular cell Mar, 2006 | Pubmed ID: 16543154
Motion as a phenotype: the use of live-cell imaging and machine visual screening to characterize transcription-dependent chromosome dynamics.
BMC cell biology , 2006 | Pubmed ID: 16635267
Pore-ing the right dose.
Nature cell biology May, 2006 | Pubmed ID: 16691206
Systems biology of gene regulation fulfills its promise.
Genome biology , 2006 | Pubmed ID: 16719937
Genomic localization of RNA binding proteins reveals links between pre-mRNA processing and transcription.
Genome research Jul, 2006 | Pubmed ID: 16769980
The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.
Genetics Sep, 2006 | Pubmed ID: 16816426
Transcriptional regulation by the proteasome as a mechanism for cellular protein homeostasis.
Cell cycle (Georgetown, Tex.) Jul, 2006 | Pubmed ID: 16861887
Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis.
Blood Jan, 2007 | Pubmed ID: 16990598
Genome-wide analysis of estrogen receptor binding sites.
Nature genetics Nov, 2006 | Pubmed ID: 17013392
The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins.
Molecular biology of the cell Dec, 2006 | Pubmed ID: 17035634
Communication between levels of transcriptional control improves robustness and adaptivity.
Molecular systems biology , 2006 | Pubmed ID: 17130867
Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors.
Genome biology , 2006 | Pubmed ID: 17137510
The role of protein arginine methylation in the formation of silent chromatin.
Genes & development Dec, 2006 | Pubmed ID: 17158743
Differential recruitment of the splicing machinery during transcription predicts genome-wide patterns of mRNA splicing.
Molecular cell Dec, 2006 | Pubmed ID: 17189192
Designing biological systems.
Genes & development Feb, 2007 | Pubmed ID: 17289915
Transcriptional regulation at the nuclear pore complex.
Current opinion in genetics & development Apr, 2007 | Pubmed ID: 17317147
Why do so few women speak at science meetings?
Nature Apr, 2007 | Pubmed ID: 17443161
Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases.
ACS chemical biology May, 2007 | Pubmed ID: 17465518
Systems perspectives on mRNA processing.
Cell research Jul, 2007 | Pubmed ID: 17621309
Exon expression profiling reveals stimulus-mediated exon use in neural cells.
Genome biology , 2007 | Pubmed ID: 17683528
Rational design of memory in eukaryotic cells.
Genes & development Sep, 2007 | Pubmed ID: 17875664
Functional specificity among ribosomal proteins regulates gene expression.
Cell Nov, 2007 | Pubmed ID: 17981122
Coupling and coordination in gene expression processes: a systems biology view.
Nature reviews. Genetics Jan, 2008 | Pubmed ID: 18071322
Global analysis of mRNA splicing.
RNA (New York, N.Y.) Feb, 2008 | Pubmed ID: 18083834
Definition of global and transcript-specific mRNA export pathways in metazoans.
Genes & development Jan, 2008 | Pubmed ID: 18086857
CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.
Cancer research Jan, 2008 | Pubmed ID: 18172323
Defossiling fuel: how synthetic biology can transform biofuel production.
ACS chemical biology Jan, 2008 | Pubmed ID: 18205286
Enhancement of cell type specificity by quantitative modulation of a chimeric ligand.
The Journal of biological chemistry Mar, 2008 | Pubmed ID: 18230610
Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes.
Genes & development Mar, 2008 | Pubmed ID: 18316479
Intron delays and transcriptional timing during development.
Developmental cell Mar, 2008 | Pubmed ID: 18331713
Intron length increases oscillatory periods of gene expression in animal cells.
Genes & development Sep, 2008 | Pubmed ID: 18703678
mRNA nuclear export and human disease.
Disease models & mechanisms Sep-Oct, 2008 | Pubmed ID: 19048072
Learning a prior on regulatory potential from eQTL data.
PLoS genetics Jan, 2009 | Pubmed ID: 19180192
Engineering a synthetic dual-organism system for hydrogen production.
Applied and environmental microbiology Apr, 2009 | Pubmed ID: 19201964
Harnessing nature's toolbox: regulatory elements for synthetic biology.
Journal of the Royal Society, Interface / the Royal Society Aug, 2009 | Pubmed ID: 19324675
A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export.
The Journal of cell biology Apr, 2009 | Pubmed ID: 19364924
Synthetic biology: exploring and exploiting genetic modularity through the design of novel biological networks.
Molecular bioSystems Jul, 2009 | Pubmed ID: 19562109
Systems-level engineering of nonfermentative metabolism in yeast.
Genetics Sep, 2009 | Pubmed ID: 19564482
Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms.
RNA (New York, N.Y.) Oct, 2009 | Pubmed ID: 19661161
Eukaryotic systems broaden the scope of synthetic biology.
The Journal of cell biology Nov, 2009 | Pubmed ID: 19948487
Anti-glycophorin single-chain Fv fusion to low-affinity mutant erythropoietin improves red blood cell-lineage specificity.
Protein engineering, design & selection : PEDS Apr, 2010 | Pubmed ID: 20083493
Making cellular memories.
Cell Jan, 2010 | Pubmed ID: 20085698
A synthetic circuit for selectively arresting daughter cells to create aging populations.
Nucleic acids research May, 2010 | Pubmed ID: 20150416
Insulation of a synthetic hydrogen metabolism circuit in bacteria.
Journal of biological engineering , 2010 | Pubmed ID: 20184755
Spatially ordered dynamics of the bacterial carbon fixation machinery.
Science (New York, N.Y.) Mar, 2010 | Pubmed ID: 20203050
Engineering cyanobacteria to synthesize and export hydrophilic products.
Applied and environmental microbiology Jun, 2010 | Pubmed ID: 20363793
Knowing when to change: reprogramming (my) life.
Nature cell biology Aug, 2010 | Pubmed ID: 20680000
An alternative splicing network links cell-cycle control to apoptosis.
Cell Aug, 2010 | Pubmed ID: 20705336
Emergent cooperation in microbial metabolism.
Molecular systems biology Sep, 2010 | Pubmed ID: 20823845
A structurally tunable DNA-based extracellular matrix.
Journal of the American Chemical Society Oct, 2010 | Pubmed ID: 20925350
Genome-wide RNAi screen discovers functional coupling of alternative splicing and cell cycle control to apoptosis regulation.
Cell cycle (Georgetown, Tex.) Nov, 2010 | Pubmed ID: 21088477
Dynamics in the mixed microbial concourse.
Genes & development Dec, 2010 | Pubmed ID: 21123647
Engineering cyanobacteria to generate high-value products.
Trends in biotechnology Feb, 2011 | Pubmed ID: 21211860
Synthetic circuit identifies subpopulations with sustained memory of DNA damage.
Genes & development Mar, 2011 | Pubmed ID: 21363961
Rewiring hydrogenase-dependent redox circuits in cyanobacteria.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 21368150
Informing biological design by integration of systems and synthetic biology.
Cell Mar, 2011 | Pubmed ID: 21414477
Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain.
Molecular biology of the cell May, 2011 | Pubmed ID: 21460183
Modular electron transfer circuits for synthetic biology: insulation of an engineered biohydrogen pathway.
Bioengineered bugs Nov-Dec, 2010 | Pubmed ID: 21468209
Towards a synthetic chloroplast.
PloS one , 2011 | Pubmed ID: 21533097
A synthetic system links FeFe-hydrogenases to essential E. coli sulfur metabolism.
Journal of biological engineering , 2011 | Pubmed ID: 21615937
Visualization of single mRNAs reveals temporal association of proteins with microRNA-regulated mRNA.
Nucleic acids research Sep, 2011 | Pubmed ID: 21653551
Synthetic reversal of epigenetic silencing.
The Journal of biological chemistry Aug, 2011 | Pubmed ID: 21669865
Recording cellular experiences of DNA damage.
Cell cycle (Georgetown, Tex.) Aug, 2011 | Pubmed ID: 21670599
Organization of intracellular reactions with rationally designed RNA assemblies.
Science (New York, N.Y.) Jul, 2011 | Pubmed ID: 21700839
Cell-to-cell variability of alternative RNA splicing.
Molecular systems biology , 2011 | Pubmed ID: 21734645
Parts plus pipes: synthetic biology approaches to metabolic engineering.
Metabolic engineering May, 2012 | Pubmed ID: 22037345
Modularity of a carbon-fixing protein organelle.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2012 | Pubmed ID: 22184212
Rerouting carbon flux to enhance photosynthetic productivity.
Applied and environmental microbiology Apr, 2012 | Pubmed ID: 22307292
A tunable zinc finger-based framework for Boolean logic computation in mammalian cells.
Nucleic acids research Jun, 2012 | Pubmed ID: 22323524
Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway.
PLoS biology , 2012 | Pubmed ID: 22389629
A sensitive switch for visualizing natural gene silencing in single cells.
ACS synthetic biology Mar, 2012 | Pubmed ID: 22530199
DNA ends alter the molecular composition and localization of Ku multicomponent complexes.
Molecular & cellular proteomics : MCP Aug, 2012 | Pubmed ID: 22535209
Engineering synthetic TAL effectors with orthogonal target sites.
Nucleic acids research May, 2012 | Pubmed ID: 22581776
Natural strategies for the spatial optimization of metabolism in synthetic biology.
Nature chemical biology Jun, 2012 | Pubmed ID: 22596204
Improving carbon fixation pathways.
Current opinion in chemical biology Aug, 2012 | Pubmed ID: 22647231
A BioBrick compatible strategy for genetic modification of plants.
Journal of biological engineering , 2012 | Pubmed ID: 22716313
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.
Genes & development Jul, 2012 | Pubmed ID: 22751500
Synthetic memory circuits for tracking human cell fate.
Genes & development Jul, 2012 | Pubmed ID: 22751502
Designing biological compartmentalization.
Trends in cell biology Dec, 2012 | Pubmed ID: 22841504
Designing and using RNA scaffolds to assemble proteins in vivo.
Nature protocols Oct, 2012 | Pubmed ID: 22955695
Spatial and temporal organization of chromosome duplication and segregation in the cyanobacterium Synechococcus elongatus PCC 7942.
PloS one , 2012 | Pubmed ID: 23112856
Expression of the sub-pathways of the Chloroflexus aurantiacus 3-hydroxypropionate carbon fixation bicycle in E. coli: Toward horizontal transfer of autotrophic growth.
Metabolic engineering Mar, 2013 | Pubmed ID: 23376595
PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth.
Genes & development Mar, 2013 | Pubmed ID: 23512658
Protein scaffold-activated protein trans-splicing in mammalian cells.
Journal of the American Chemical Society May, 2013 | Pubmed ID: 23621664
Tailored fatty acid synthesis via dynamic control of fatty acid elongation.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2013 | Pubmed ID: 23798438
Dynamics simulations for engineering macromolecular interactions.
Chaos (Woodbury, N.Y.) Jun, 2013 | Pubmed ID: 23822508
Isothermal self-assembly of complex DNA structures under diverse and biocompatible conditions.
Nano letters Sep, 2013 | Pubmed ID: 23978049
Two- and three-input TALE-based AND logic computation in embryonic stem cells.
Nucleic acids research Nov, 2013 | Pubmed ID: 23982518
Targeting a heterologous protein to multiple plant organelles via rationally designed 5' mRNA tags.
Journal of biological engineering , 2013 | Pubmed ID: 24011257
The bacterial carbon-fixing organelle is formed by shell envelopment of preassembled cargo.
PloS one , 2013 | Pubmed ID: 24023971
Building synthetic memory.
Current biology : CB Sep, 2013 | Pubmed ID: 24028965
Rapid construction of insulated genetic circuits via synthetic sequence-guided isothermal assembly.
Nucleic acids research Jan, 2014 | Pubmed ID: 24078086
An objective function exploiting suboptimal solutions in metabolic networks.
BMC systems biology , 2013 | Pubmed ID: 24088221
Building synthetic cellular organization.
Molecular biology of the cell Dec, 2013 | Pubmed ID: 24288075
Synthetic biology in mammalian cells: next generation research tools and therapeutics.
Nature reviews. Molecular cell biology Feb, 2014 | Pubmed ID: 24434884
HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism.
Cell reports Mar, 2014 | Pubmed ID: 24613350
Programmable bacteria detect and record an environmental signal in the mammalian gut.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2014 | Pubmed ID: 24639514
Integrating Biological Redesign: Where Synthetic Biology Came From and Where It Needs to Go.
Cell Mar, 2014 | Pubmed ID: 24679533
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