Claire Marie Filone

Presence of broadly reactive and group-specific neutralizing epitopes on newly described isolates of Crimean-Congo hemorrhagic fever virus.

N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry.

Development and characterization of a Rift Valley fever virus cell-cell fusion assay using alphavirus replicon vectors.

Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling.

Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon.

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection.

Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library.

Filoviruses require endosomal cysteine proteases for entry but exhibit distinct protease preferences.

Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach.

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.

Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication.