Stephan E. Lehnart

Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium.

Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium.

Coronary perfusion cocktails for in vivo gene transfer.

PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure.

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.

Immunophilins and coupled gating of ryanodine receptors.

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak.

Cardiac ryanodine receptor function and regulation in heart disease.

Calstabin deficiency, ryanodine receptors, and sudden cardiac death.

Intracellular calcium release and cardiac disease.

Defective cardiac ryanodine receptor regulation during atrial fibrillation.

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.

Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure.

Ryanodine receptor-targeted anti-arrhythmic therapy.

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.

Phosphodiesterase 4D and heart failure: a cautionary tale.

Novel targets for treating heart and muscle disease: stabilizing ryanodine receptors and preventing intracellular calcium leak.

Modulation of the ryanodine receptor and intracellular calcium.

Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function.

Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity.

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.

Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency.

Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins.

Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart.

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum.

An antidote for calcium leak: targeting molecular arrhythmia mechanisms.

Differential cardiac remodeling in preload versus afterload.

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes.

Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype.

Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion.

Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction.

Understanding the physiology of heart failure through cellular and in vivo models-towards targeting of complex mechanisms.

Superresolution microscopy in heart - cardiac nanoscopy.

Imaging T-tubules: dynamic membrane structures for deep functions.

Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes.

Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes.

Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias.