Hak-Kim Chan

Solubility prediction of anthracene in mixed solvents using a minimum number of experimental data.

A solid-state NMR study of protein mobility in lyophilized protein-sugar powders.

Solubility prediction in supercritical CO(2) using minimum number of experiments.

A cosolvency model to predict solubility of drugs at several temperatures from a limited number of solubility measurements.

Effect of powder polydispersity on aerosol generation.

Mathematical representation of apparent dissociation constants in aqueous-organic solvent mixtures.

Changes in lung deposition of aerosols due to hygroscopic growth: a fast SPECT study.

The role of particle properties in pharmaceutical powder inhalation formulations.

Mannitol as a challenge test to identify exercise-induced bronchoconstriction in elite athletes.

Comparison of different algorithms to calculate electrophoretic mobility of analytes as a function of binary solvent composition.

Novel alternative methods for the delivery of drugs for the treatment of asthma.

Inhalation challenge with bovine dander allergens: who needs it?

Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma.

Responsiveness to three bronchial provocation tests in patients with asthma.

Feasibility of preparing nanodrugs by high-gravity reactive precipitation.

A simple relationship between dielectric constant of mixed solvents with solvent composition and temperature.

Generation of fine powders of recombinant human deoxyribonuclease using the aerosol solvent extraction system.

Physical stability of salmon calcitonin spray-dried powders for inhalation.

Coughing during mannitol challenge is associated with asthma.

Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length.

Effect of mouthpiece washing on aerosol performance of CFC-free Ventolin.

Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept.

Modeling the entrainer effects on solubility of solutes in supercritical carbon dioxide.

How much particle surface corrugation is sufficient to improve aerosol performance of powders?

A unified cosolvency model for calculating solute solubility in mixed solvents.

The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses.

Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses.

Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects.

Effect of amino acids on the dispersion of disodium cromoglycate powders.

Electrostatic charge characteristics of aerosols produced from metered dose inhalers.

The 15th International Society of Aerosols in Medicine Congress. Perth, Australia, 14-18 March 2005.

SPECT Imaging for Radioaerosol Deposition and Clearance Studies.

Dry powder aerosol delivery systems: current and future research directions.

Solubility prediction of paracetamol in binary and ternary solvent mixtures using Jouyban-Acree model.

Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size.

Production of salbutamol sulfate for inhalation by high-gravity controlled antisolvent precipitation.

The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders.

Lung deposition of mannitol powder aerosol in healthy subjects.

Influence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systems.

Focused-ion-beam milling: a novel approach to probing the interior of particles used for inhalation aerosols.

Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhaler.

The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance.

Effect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosols.

Preparation of inhalable salbutamol sulphate using reactive high gravity controlled precipitation.

The influence of drug morphology on aerosolisation efficiency of dry powder inhaler formulations.

Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers.

Cospray dried antibiotics for dry powder lung delivery.

In vitro and in vivo aspects of cascade impactor tests and inhaler performance: a review.

Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles.

Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: influence of polymer concentration on physical and in vitro characteristics.

What is a suitable dissolution method for drug nanoparticles?

Physicochemical characterization and stability of rifampicin liposome dry powder formulations for inhalation.

In vitro/in vivo comparisons in pulmonary drug delivery.

Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols.

Dissolution kinetic behavior of drug nanoparticles and their conformity to the diffusion model.

Micro-particle corrugation, adhesion and inhalation aerosol efficiency.

What is the role of particle morphology in pharmaceutical powder aerosols?

Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation.

Lactose composite carriers for respiratory delivery.

Introduction of the electrical next generation impactor (eNGI) and investigation of its capabilities for the study of pressurized metered dose inhalers.

Preparation and evaluation of controlled release microparticles for respiratory protein therapy.

Recent advances in controlled release pulmonary therapy.

Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI).

Development of an in vivo ovine dry powder inhalation model for the evaluation of conventional and controlled release microparticles.

Controlled release antibiotics for dry powder lung delivery.

The influence of flow rate on the aerosol deposition profile and electrostatic charge of single and combination metered dose inhalers.

Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines.

Does electrostatic charge affect powder aerosolisation?

Electrostatics of pharmaceutical inhalation aerosols.

A novel method for the production of crystalline micronised particles.

Can low-dose combination products for inhalation be formulated in single crystalline particles?

The contribution of different formulation components on the aerosol charge in carrier-based dry powder inhaler systems.

Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease.

Particle aerosolisation and break-up in dry powder inhalers 1: evaluation and modelling of venturi effects for agglomerated systems.

Electrostatic charge characteristics of jet nebulized aerosols.

Impact angles as an alternative way to improve aerosolisation of powders for inhalation?

Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy.

Method to introduce mannitol powder to intubated patients to improve sputum clearance.

Formation, characterization, and fate of inhaled drug nanoparticles.

Pulmonary formulations: what remains to be done?

Formation of protein nano-matrix particles with controlled surface architecture for respiratory drug delivery.

Mannitol delivery by vibrating mesh nebulisation for enhancing mucociliary clearance.

Pulmonary delivery of therapeutic siRNA.

Particle aerosolisation and break-up in dry powder inhalers: evaluation and modelling of impaction effects for agglomerated systems.

Production methods for nanodrug particles using the bottom-up approach.

Nanodrug particles and nanoformulations for drug delivery.

Particle aerosolisation and break-up in dry powder inhalers: evaluation and modelling of the influence of grid structures for agglomerated systems.

Isoniazid proliposome powders for inhalation-preparation, characterization and cell culture studies.

Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former.

The use of computational approaches in inhaler development.

Constant size, variable density aerosol particles by ultrasonic spray freeze drying.

Does the United States Pharmacopeia throat introduce de-agglomeration of carrier-free powder from inhalers?

Delivery of high solubility polyols by vibrating mesh nebulizer to enhance mucociliary clearance.

Personalizing aerosol medicine: development of delivery systems tailored to the individual.

A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics.

Synergistic combination dry powders for inhaled antimicrobial therapy: Formulation, characterization and in vitro evaluation.

Standardization of techniques for using single-photon emission computed tomography (SPECT) for aerosol deposition assessment of orally inhaled products.

Validation of radiolabeling of drug formulations for aerosol deposition assessment of orally inhaled products.

Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research.

Effect of device design on the aerosolization of a carrier-based dry powder inhaler--a case study on Aerolizer(®) Foradile (®).

Unitary hormonal models, peripheral markers, and evaluation of response to drug: a response to Weisman and Feldman.

Nanotechnology versus other techniques in improving drug dissolution.

Novel alternatives to reduce powder retention in the dry powder inhaler during aerosolization.

Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids.

TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines.

Aerosol delivery of nanoparticles in uniform mannitol carriers formulated by ultrasonic spray freeze drying.

Colistin powders with high aerosolisation efficiency for respiratory infection: preparation and in vitro evaluation.

Pulmonary drug delivery.

Electrostatics in pharmaceutical aerosols for inhalation.

Liposomal formulations for inhalation.

Overcoming dose limitations using the orbital(®) multi-breath dry powder inhaler.

The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers.

Synergistic antibiotic combination powders of colistin and rifampicin provide high aerosolization efficiency and moisture protection.

Inhaled antibiotics to treat lung infection.

A rifapentine-containing inhaled triple antibiotic formulation for rapid treatment of tubercular infection.

Delivery of inhalation drugs to children for asthma and other respiratory diseases.

The influence of actuator materials and nozzle designs on electrostatic charge of pressurised metered dose inhaler (pMDI) formulations.

Effect of crystallinity on electrostatic charging in dry powder inhaler formulations.

Steroid-decorated antibiotic microparticles for inhaled anti-infective therapy.

A novel inhalable form of rifapentine.

Nanodrugs: pharmacokinetics and safety.

Modifying the release properties of liposomes toward personalized medicine.

Advances in Device and Formulation Technologies for Pulmonary Drug Delivery.

Emerging inhalation aerosol devices and strategies: Where are we headed?

Isothermal Microcalorimetry of Pressurized Systems I: A Rapid Method to Evaluate Pressurized Metered Dose Inhaler Formulations.

Multi-breath dry powder inhaler for delivery of cohesive powders in the treatment of bronchiectasis.

Pulmonary drug delivery by powder aerosols.

Attachment of micro- and nano-particles on tipless cantilevers for colloidal probe microscopy.

NanoXCT: A Novel Technique to Probe the Internal Architecture of Pharmaceutical Particles.

Aerosol Performance and Long-Term Stability of Surfactant-Associated Liposomal Ciprofloxacin Formulations with Modified Encapsulation and Release Properties.