Eric S. Lander

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia.

ARACHNE: a whole-genome shotgun assembler.

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning.

Human macrophage activation programs induced by bacterial pathogens.

Prediction of central nervous system embryonal tumour outcome based on gene expression.

On the sequencing of the human genome.

The structure of haplotype blocks in the human genome.

Gene expression correlates of clinical prostate cancer behavior.

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.

Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.

Human genome sequence variation and the influence of gene history, mutation and recombination.

Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei.

Detecting recent positive selection in the human genome from haplotype structure.

Detection of regulatory variation in mouse genes.

Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells.

Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci.

Initial sequencing and comparative analysis of the mouse genome.

The mosaic structure of variation in the laboratory mouse genome.

A molecular signature of metastasis in primary solid tumors.

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease.

Whole-genome sequence assembly for mammalian genomes: Arachne 2.

Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics.

More on the sequencing of the human genome.

Pathogen discovery from human tissue by sequence-based computational subtraction.

The genome sequence of the filamentous fungus Neurospora crassa.

Sequencing and comparison of yeast species to identify genes and regulatory elements.

IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis.

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.

Phylogenetically and spatially conserved word pairs associated with gene-expression changes in yeasts.

An integrated haplotype map of the human major histocompatibility complex.

Position specific variation in the rate of evolution in transcription factor binding sites.

Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.

Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae.

Genetic dissection of complex traits with chromosome substitution strains of mice.

Assessing the impact of population stratification on genetic association studies.

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.

Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains.

Methods in comparative genomics: genome correspondence, gene identification and regulatory motif discovery.

Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.

Transcriptional regulatory code of a eukaryotic genome.

Eric S. Lander.

Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.

Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.

Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype.

A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.

Genomic maps and comparative analysis of histone modifications in human and mouse.

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals.

A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.

An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing.

Assembly of polymorphic genomes: algorithms and application to Ciona savignyi.

A high-density screen for linkage in multiple sclerosis.

DNA sequence and analysis of human chromosome 18.

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis.

The case for selection at CCR5-Delta32.

Genome sequence, comparative analysis and haplotype structure of the domestic dog.

Searching for signals of evolutionary selection in 168 genes related to immune function.

DNA sequence and analysis of human chromosome 8.

A large family of ancient repeat elements in the human genome is under strong selection.

Human chromosome 11 DNA sequence and analysis including novel gene identification.

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

Analysis of the DNA sequence and duplication history of human chromosome 15.

Reactive oxygen species have a causal role in multiple forms of insulin resistance.

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

Identification and classification of conserved RNA secondary structures in the human genome.

A bivalent chromatin structure marks key developmental genes in embryonic stem cells.

Genetic evidence for complex speciation of humans and chimpanzees.

A family of conserved noncoding elements derived from an ancient transposable element.

Genome-scale loss-of-function screening with a lentiviral RNAi library.

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

A second fatty acid amide hydrolase with variable distribution among placental mammals.

Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida.

Chromosome substitution strains: a new way to study genetically complex traits.

A genome-wide map of diversity in Plasmodium falciparum.

A second major histocompatibility complex susceptibility locus for multiple sclerosis.

The mammalian epigenome.

Sleep-related epilepsy in the A/J mouse.

Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites.

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.

Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome.

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.

Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.

Risk alleles for multiple sclerosis identified by a genomewide study.

Comment on "The consensus coding sequences of human breast and colorectal cancers".

Efficient mapping of mendelian traits in dogs through genome-wide association.

Genome-wide detection and characterization of positive selection in human populations.

Characterizing the cancer genome in lung adenocarcinoma.

28-way vertebrate alignment and conservation track in the UCSC Genome Browser.

Distinguishing protein-coding and noncoding genes in the human genome.

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.

Quality scores and SNP detection in sequencing-by-synthesis systems.

ALLPATHS: de novo assembly of whole-genome shotgun microreads.

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways.

Dissecting direct reprogramming through integrative genomic analysis.

Genome-scale DNA methylation maps of pluripotent and differentiated cells.

Somatic mutations affect key pathways in lung adenocarcinoma.

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.

Genetic mapping in human disease.

Sequencing the nuclear genome of the extinct woolly mammoth.

High-resolution mapping of copy-number alterations with massively parallel sequencing.

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.

Highly parallel identification of essential genes in cancer cells.

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.

Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing.

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.

Identification of selective inhibitors of cancer stem cells by high-throughput screening.

Assisted assembly: how to improve a de novo genome assembly by using related species.

Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.

ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.

A composite of multiple signals distinguishes causal variants in regions of positive selection.

Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution.

CK1epsilon is required for breast cancers dependent on beta-catenin activity.

Genetic resistance to diet-induced obesity in chromosome substitution strains of mice.

The landscape of somatic copy-number alteration across human cancers.

Integrative analysis of the melanoma transcriptome.

International network of cancer genome projects.

Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs.

A draft sequence of the Neandertal genome.

Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.

A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes.

Comparative epigenomic analysis of murine and human adipogenesis.

Prepare and inspire.

The NIH Roadmap Epigenomics Mapping Consortium.

Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.

Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling.

High-quality draft assemblies of mammalian genomes from massively parallel sequence data.

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.

Integrative genomics viewer.

Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.

Initial impact of the sequencing of the human genome.

The genomic complexity of primary human prostate cancer.

Genome-sequencing anniversary. The accelerator.

Initial genome sequencing and analysis of multiple myeloma.

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

QnAs with Eric S. Lander. Interview by Prashant Nair.

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.

The mutational landscape of head and neck squamous cell carcinoma.

Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.

lincRNAs act in the circuitry controlling pluripotency and differentiation.

The genome of the green anole lizard and a comparative analysis with birds and mammals.

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.

A high-resolution map of human evolutionary constraint using 29 mammals.

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.

Detecting novel associations in large data sets.

The mystery of missing heritability: Genetic interactions create phantom heritability.

Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011.