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Department of Cell and Molecular Biology
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Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion.
Investigative ophthalmology & visual science Nov, 2002 | Pubmed ID: 12407162
In vivo transduction of photoreceptors or ciliary body by intravitreal injection of pseudotyped adenoviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2003 | Pubmed ID: 12573615
Endothelial proliferation in diabetic retinal microaneurysms.
Archives of ophthalmology May, 2003 | Pubmed ID: 12742861
Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina.
Blood May, 2004 | Pubmed ID: 14726407
Global gene expression analysis of the developing postnatal mouse retina.
Investigative ophthalmology & visual science Mar, 2004 | Pubmed ID: 14985324
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling.
Nature medicine May, 2004 | Pubmed ID: 15098027
Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease.
Investigative ophthalmology & visual science Sep, 2005 | Pubmed ID: 16123396
T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification.
Investigative ophthalmology & visual science May, 2006 | Pubmed ID: 16639024
Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy.
The Journal of clinical investigation Dec, 2006 | Pubmed ID: 17111048
Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2007 | Pubmed ID: 17210921
Ocular neovascularization: basic mechanisms and therapeutic advances.
Survey of ophthalmology Jan, 2007 | Pubmed ID: 17240254
Progenitor cells and retinal angiogenesis.
Angiogenesis , 2007 | Pubmed ID: 17372851
Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits.
The Journal of clinical investigation Jun, 2008 | Pubmed ID: 18483622
Chapter 6. Ocular models of angiogenesis.
Methods in enzymology , 2008 | Pubmed ID: 19007663
Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress.
The Journal of clinical investigation Mar, 2009 | Pubmed ID: 19188685
Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy.
Glia Jan, 2010 | Pubmed ID: 19544395
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina.
Glia Aug, 2010 | Pubmed ID: 20544853
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye.
The Journal of cell biology Nov, 2011 | Pubmed ID: 22084310
Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy.
Scientific reports , 2011 | Pubmed ID: 22355595
Targeted deletion of Vegfa in adult mice induces vision loss.
The Journal of clinical investigation Nov, 2012 | Pubmed ID: 23093773
Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting.
The Journal of clinical investigation Nov, 2013 | Pubmed ID: 24084735
Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye.
EMBO molecular medicine May, 2014 | Pubmed ID: 24705878
The Scripps Research Institute
Peter D. Westenskow1,2,
Toshihide Kurihara1,
Stephen Bravo1,
Daniel Feitelberg1,
Zack A. Sedillo2,
Edith Aguilar1,
Martin Friedlander1,2
1Department of Cell and Molecular Biology, The Scripps Research Institute,
2, Lowy Medical Research Institute
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