Jan Marik

A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries.

Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase.

Design, synthesis, screening, and decoding of encoded one-bead one-compound peptidomimetic and small molecule combinatorial libraries.

Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible.

Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cells.

Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid.

Identification of novel targeting peptides for human ovarian cancer cells using "one-bead one-compound" combinatorial libraries.

Near-infrared optical imaging of ovarian cancer xenografts with novel alpha 3-integrin binding peptide "OA02".

Peptide and small-molecule microarrays.

Peptide ligands targeting integrin alpha3beta1 in non-small cell lung cancer.

Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging.

Solid-phase synthesis of 2-[18F]fluoropropionyl peptides.

Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU).

The minimum element of a synthetic peptide required to block prostate tumor cell migration.

Long-circulating liposomes radiolabeled with [18F]fluorodipalmitin ([18F]FDP).

Use of a peptide derived from foot-and-mouth disease virus for the noninvasive imaging of human cancer: generation and evaluation of 4-[18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alphavbeta6 expression with positron emission tomography.

From combinatorial chemistry to cancer-targeting peptides.

Evaluation of ketone-oxime method for developing therapeutic on-demand cleavable immunoconjugates.

Dynamic microPET imaging of ultrasound contrast agents and lipid delivery.

In vivo positron emission tomography (PET) imaging with an alphavbeta6 specific peptide radiolabeled using 18F-"click" chemistry: evaluation and comparison with the corresponding 4-[18F]fluorobenzoyl- and 2-[18F]fluoropropionyl-peptides.

Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method.

PET of glial metabolism using 2-18F-fluoroacetate.

Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model.

A modular platform for the rapid site-specific radiolabeling of proteins with 18F exemplified by quantitative positron emission tomography of human epidermal growth factor receptor 2.

High-throughput in vivo screening of targeted molecular imaging agents.

Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET.

Development and evaluation of a novel method for preclinical measurement of tissue vascular volume.

Emerging role of immunoPET in receptor targeted cancer therapy.

The development of peptide-based tools for the analysis of angiogenesis.

Preparation of 18F-labeled peptides using the copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition.

Immuno-PET of the hepatocyte growth factor receptor Met using the 1-armed antibody onartuzumab.

ImmunoPET imaging of phosphatidylserine in pro-apoptotic therapy treated tumor models.

Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies.

Evaluation of 2-[¹⁸F]fluoroacetate kinetics in rodent models of cerebral hypoxia-ischemia.

New imaging paradigms in drug development: the PET imaging approach.