Mindy Tsai

Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo.

Analyzing the roles of mast cells and basophils in host defense and other biological responses.

Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11.

Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.

Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus.

Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice.

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.

Immune sensitization in the skin is enhanced by antigen-independent effects of IgE.

RabGEF1 is a negative regulator of mast cell activation and skin inflammation.

Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.

Mast cells in the development of adaptive immune responses.

Mast cells as "tunable" effector and immunoregulatory cells: recent advances.

Mast cells enhance T cell activation: Importance of mast cell-derived TNF.

Identification of mast cell progenitors in adult mice.

Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo.

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.

Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response.

Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF.

RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells.

Mast cell-associated TNF promotes dendritic cell migration.

Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells.

RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation.

Mast cells can promote the development of multiple features of chronic asthma in mice.

Mast cells can enhance resistance to snake and honeybee venoms.

Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses.

Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice.

TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice.

Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells.

Mast cells in the promotion and limitation of chronic inflammation.

Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.

Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis.

Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity.

The development of allergic inflammation.

IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro.

The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice.

Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.

Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity.

Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice.

Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy.

Evidence that the endothelin A receptor can enhance IgE-dependent anaphylaxis in mice.

Mast cells and immunoregulation/immunomodulation.

Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma.

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.

IgE and mast cells in allergic disease.

Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.

The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.

Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice.

Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice.

Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells.

Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice.

A beneficial role for immunoglobulin E in host defense against honeybee venom.

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).

Mast cells: potential positive and negative roles in tumor biology.

Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice.

Evidence that meningeal mast cells can worsen stroke pathology in mice.

Approaches for analyzing the roles of mast cells and their proteases in vivo.