Stephen J. Galli

In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo.

Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice.

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis.

Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo.

Analyzing the roles of mast cells and basophils in host defense and other biological responses.

Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11.

Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease.

Regulation of mast-cell and basophil function and survival by IgE.

Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.

Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus.

Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice.

Involvement of both 'allergic' and 'autoimmune' mechanisms in EAE, MS and other autoimmune diseases.

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.

Mast cells to the defense.

Chair's introduction. Anaphylaxis.

Immune sensitization in the skin is enhanced by antigen-independent effects of IgE.

RabGEF1 is a negative regulator of mast cell activation and skin inflammation.

Lack of significant skin inflammation during elimination by apoptosis of large numbers of mouse cutaneous mast cells after cessation of treatment with stem cell factor.

Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.

Mast cells in the development of adaptive immune responses.

Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors.

Pathogenesis and management of anaphylaxis: current status and future challenges.

Symposium on the definition and management of anaphylaxis: summary report.

Mast cells as "tunable" effector and immunoregulatory cells: recent advances.

Nipping cat allergy with fusion proteins.

Mast cells enhance T cell activation: Importance of mast cell-derived TNF.

Adoptive transfer of mast cells does not enhance the impaired survival of Kit(W)/Kit(W-v) mice in a model of low dose intraperitoneal infection with bioluminescent Salmonella typhimurium.

Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation.

Identification of mast cell progenitors in adult mice.

Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo.

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.

Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response.

A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice.

Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF.

Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.

RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells.

Second symposium on the definition and management of anaphylaxis: summary report--second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.

Mast cell-associated TNF promotes dendritic cell migration.

Interleukin-4-triggered, STAT6-dependent production of a factor that induces mouse mast cell apoptosis.

Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells.

RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation.

Mast cells can promote the development of multiple features of chronic asthma in mice.

Mast cells can enhance resistance to snake and honeybee venoms.

Interleukin-3 and c-Kit/stem cell factor are required for normal eosinophil responses in mice infected with Strongyloides venezuelensis.

Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses.

Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice.

Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice.

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17.

TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice.

Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells.

Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice.

Mast cells in the promotion and limitation of chronic inflammation.

TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.

IL-33 can promote survival, adhesion and cytokine production in human mast cells.

Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.

IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.

Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis.

Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.

Basophils are back!

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity.

The development of allergic inflammation.

Rabaptin-5 regulates receptor expression and functional activation in mast cells.

Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis.

New developments in mast cell biology.

IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro.

Anaphylaxis to a self-peptide in the absence of mast cells or histamine.

The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice.

Pillars article: fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient w/wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.

Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.

Localization of anionic constituents in mast cell granules of brachymorphic (bm/bm) mice by using avidin-conjugated colloidal gold.

Evidence that vitamin D(3) promotes mast cell-dependent reduction of chronic UVB-induced skin pathology in mice.

Distinguishing mast cell and granulocyte differentiation at the single-cell level.

Regulation of secretory granule size by the precise generation and fusion of unit granules.

Anaphylaxis: mechanisms of mast cell activation.

Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity.

Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice.

Antiinflammatory and immunosuppressive functions of mast cells.

Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy.

The role of mast cells in atrial natriuretic peptide-induced cutaneous inflammation.

Evidence that the endothelin A receptor can enhance IgE-dependent anaphylaxis in mice.

Mast cells and immunoregulation/immunomodulation.

Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma.

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils.

Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients.

IgE and mast cells in allergic disease.

Critical role of P1-Runx1 in mouse basophil development.

Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.

The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.

Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice.

New models for analyzing mast cell functions in vivo.

Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice.

PLA2G3 promotes mast cell maturation and function.

Mast cells are required for full expression of allergen/SEB-induced skin inflammation.

Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells.

Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice.

Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells.

A beneficial role for immunoglobulin E in host defense against honeybee venom.

Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation.

[An allergic response to fight against venoms].

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).

Mast cells: potential positive and negative roles in tumor biology.

Rethinking the potential roles of mast cells in skin wound healing and bleomycin-induced skin fibrosis.

Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice.

Evidence that meningeal mast cells can worsen stroke pathology in mice.

Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin Inflammation.

A Balanced Look at the Implications of Genomic (and Other "Omics") Testing for Disease Diagnosis and Clinical Care.

Potential effector and immunoregulatory functions of mast cells in mucosal immunity.

Approaches for analyzing the roles of mast cells and their proteases in vivo.

Computational Pathology: A Path Ahead.

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.

Testing the 'toxin hypothesis of allergy': mast cells, IgE, and innate and acquired immune responses to venoms.

SnapShot: Integrated Type 2 Immune Responses.

Editorial overview: Allergy and hypersensitivity: New developments in allergy and type 2 immunity: never a dull moment.

IgE antibodies, FcεRIα, and IgE-mediated local anaphylaxis can limit snake venom toxicity.

Evidence that β7 Integrin Regulates Hematopoietic Stem Cell Homing and Engraftment Through Interaction with MAdCAM-1.

The adherens junctions control susceptibility to Staphylococcus aureus α-toxin.

Mast cells and IgE in defense against venoms: Possible "good side" of allergy?

The Mast Cell-IgE Paradox: From Homeostasis to Anaphylaxis.

Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets.

Molecular and cellular mechanisms of food allergy and food tolerance.

Toward precision medicine and health: Opportunities and challenges in allergic diseases.

IgE and mast cells in host defense against parasites and venoms.

IgG subclasses determine pathways of anaphylaxis in mice.

Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis.

Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis.

Different activation signals induce distinct mast cell degranulation strategies.

The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation.

Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.

Neutrophils are not required for resolution of acute gouty arthritis in mice.

A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice.

Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.

Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4 T Cells and ILC2 Cells in Primary and Secondary Immunity to Strongyloides venezuelensis.

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children.

Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide.

Reply.

Imaging protective mast cells in living mice during severe contact hypersensitivity.

Mast Cells and KIT as Potential Therapeutic Targets in Severe Asthma.

A new fluorescent-avidin-based method for quantifying basophil activation in whole blood.

Human mast cells as antigen-presenting cells: When is this role important in vivo?

The pathophysiology of anaphylaxis.

Mast Cells and IgE can Enhance Survival During Innate and Acquired Host Responses to Venoms.

Immune monitoring for precision medicine in allergy and asthma.

The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice.

Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis.

Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal.

Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial.

Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE.

Food allergy and omics.

Mast cells as sources of cytokines, chemokines, and growth factors.

Thirdhand smoke component can exacerbate a mouse asthma model through mast cells.

Development of a tool predicting severity of allergic reaction during peanut challenge.

Between hype and hope: whole-genome sequencing in clinical medicine.

Genomics in the clinic: ethical and policy challenges in clinical next-generation sequencing programs at early adopter USA institutions.

Effect of Dietary Fiber and Metabolites on Mast Cell Activation and Mast Cell-Associated Diseases.